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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 840 - 853 (14page)
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Background: Recent evidences indicate that early rapid renal function decline is closely associated with the development and progression of diabetic kidney disease. We have investigated the association between carotid atherosclerosis and rapid renal function decline in patients with type 2 diabetes mellitus and preserved renal function. Methods: In a prospective, multicenter cohort, a total of 967 patients with type 2 diabetes mellitus and preserved renal function were followed for 6 years with serial estimated glomerular filtration rate (eGFR) measurements. Common carotid intima-media thickness (CIMT) and presence of carotid plaque were assessed at baseline. Rapid renal function decline was defined as an eGFR decline >3.3% per year. Results: Over a median follow-up of 6 years, 158 participants (16.3%) developed rapid renal function decline. While there was no difference in CIMT, the presence of carotid plaque in rapid decliners was significantly higher than in non-decliners (23.2% vs. 12.2%, P<0.001). In multivariable logistic regression analysis, presence of carotid plaque was an independent predictor of rapid renal function decline (odds ratio, 2.33; 95% confidence interval, 1.48 to 3.68; P<0.0001) after adjustment for established risk factors. The model including the carotid plaque had better performance for discrimination of rapid renal function decline than the model without carotid plaque (area under the receiver operating characteristic curve 0.772 vs. 0.744, P=0.016). Conclusion: Close monitoring of renal function and early intensive management may be beneficial in patients with type 2 diabetes mellitus and carotid plaques.
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참고문헌 (46)
참고문헌 신청
Martinez-Castelao A / 2015 / The concept and the epidemiology of diabetic nephropathy have changed in recent years / J Clin Med 4:1207~1216
Retnakaran R / 2006 / Risk factors for renal dysfunction in type 2 diabetes: U.K. Prospective Diabetes Study 74 / Diabetes 55:1832~1839
Kramer HJ / 2003 / Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus / JAMA 289:3273~3277
Mogensen CE / 1984 / Predicting diabetic nephropathy in insulin-dependent patients / N Engl J Med 311:89~93
Perkins BA / 2007 / Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes / J Am Soc Nephrol 18:1353~1361
Retnakaran R / 2006 / Risk factors for renal dysfunction in type 2 diabetes: U.K. Prospective Diabetes Study 74 / Diabetes 55:1832~1839
Kramer HJ / 2003 / Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus / JAMA 289:3273~3277
Mogensen CE / 1984 / Predicting diabetic nephropathy in insulin-dependent patients / N Engl J Med 311:89~93
Perkins BA / 2007 / Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes / J Am Soc Nephrol 18:1353~1361
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