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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background and Purpose Carotid plaques are a strong risk factor for ischemic stroke, and plaquerupture poses an even higher risk. Although many studies have investigated the pathogenicmechanisms of carotid plaque formation, few have studied the differences in molecular mechanisms underlying the rupture and non-rupture of carotid plaques. In addition, since early diagnosis and treatment of carotid plaque rupture are critical for the prevention of ischemic stroke, many studies have sought to identify the important target molecules involved in the rupture. However, a target molecule critical in symptomatic ruptured plaques is yet to be identified. Methods A total of 79 carotid plaques were consecutively collected, and microscopically divided into ruptured and non-ruptured groups. Quantitative polymerase chain reaction array, proteomics, and immunohistochemistry were performed to compare the differences in molecular mechanisms between ruptured and non-ruptured plaques. Enzyme-linked immunosorbent assay was used to measure the differences in ATP-binding cassette subfamily A member 1 (ABCA1) levels in the serum. Results The expression of several mRNAs and proteins, including ABCA1, was higher in ruptured plaques than non-ruptured plaques. In contrast, the expression of other proteins, including β-actin, was lower in ruptured plaques than non-ruptured plaques. The increased expression of ABCA1 was consistent across several experiments, ABCA1 was positive only in the serum of patients with symptomatic ruptured plaques. Conclusions This study introduces a plausible molecular mechanism underlying carotid plaquerupture, suggesting that ABCA1 plays a role in symptomatic rupture. Further study of ABCA1 is needed to confirm this hypothesis.
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참고문헌 (41)
참고문헌 신청
Mughal MM / 2011 / Symptomatic and asymptomatic carotid artery plaque / Expert Rev Cardiovasc Ther 9:1315~1330
North American Symptomatic Carotid Endarterectomy Trial Collaborators / 1991 / Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis / N Engl J Med 325:445~453
Executive Committee for the Asymptomatic Carotid Atherosclerosis Study / 1995 / Endarterectomy for asymptomatic carotid artery stenosis / JAMA 273:1421~1428
Halliday A / 2004 / Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial / Lancet 363:1491~1502
Prabhakaran S / 2006 / Carotid plaque surface irregularity predicts ischemic stroke: the northern Manhattan study / Stroke 37:2696~2701
North American Symptomatic Carotid Endarterectomy Trial Collaborators / 1991 / Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis / N Engl J Med 325:445~453
Executive Committee for the Asymptomatic Carotid Atherosclerosis Study / 1995 / Endarterectomy for asymptomatic carotid artery stenosis / JAMA 273:1421~1428
Halliday A / 2004 / Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial / Lancet 363:1491~1502
Prabhakaran S / 2006 / Carotid plaque surface irregularity predicts ischemic stroke: the northern Manhattan study / Stroke 37:2696~2701
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