지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 699 - 705 (7page)
이용수
초록· 키워드
오류제보하기
Background and Objectives: Non-calcified carotid plaques are more unstable than calcified plaques, and they are associated with a higher risk of rupture, thromboembolism, and consequently, stroke. The purpose of the present study is to compare calcified and non-calcified plaques that cause intermediate carotid artery stenosis with respect to neutrophil/lymphocyte ratio (NLR). Subjects and Methods: A total number of 139 asymptomatic patients with 50-70% stenosis of the carotid artery were included in this study. Carotid Doppler ultrasound imaging and computed tomography angiography were performed to divide the carotid artery plaques into two groups as calcified and non-calcified. Patients included in the calcified (n=73) and non-calcified (n=66) plaque groups were compared with respect to total neutrophil count, lymphocyte count and NLR. Results: Total lymphocyte count was statistically significantly lower in the non-calcified plaque group compared to the calcified plaque group (total lymphocyte count in non-calcified/calcified plaque groups [103/mm3]: 2.1/2.3, respectively) (p=0.002). NLR was statistically significantly higher in the non-calcified plaque group compared to the calcified plaque group (NLR in non-calcified/calcified plaque groups: 2.6/2.1, respectively) (p<0.001). The cut-off value for NLR was found to be >2.54. Multivariate regression analysis showed that NLR was independently associated with non-calcified carotid artery plaques (odds ratio 5.686, 95% CI 2.498-12.944, p<0.001). Conclusions: NLR is increased in the presence of non-calcified carotid artery plaques that cause asymptomatic intermediate stenosis. Increased NLR can be used as a marker to assess the risk of rupture of non-calcified carotid artery plaques.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Gorelick PB / 2008 / Large artery intracranial occlusive disease: a large worldwide burden but a relatively neglected frontier / Stroke 39:2396~2399
Cybulsky MI / 1991 / Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis / Science 251:788~791
Kolodgie FD / 2001 / The thin-cap fibroatheroma: A type of vulnerable plaque: The major precursor lesion to acute coronary syndromes / Curr Opin Cardiol 16:285~292
Drechsler M / 2010 / Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis / Circulation 122:1837~1845
Larionov S / 2007 / Expression of alpha2-macroglobulin, neutrophil elastase, and interleukin-1alpha differs in early-stage and late-stage atherosclerotic lesions in the arteries of the circle of Willis / Acta Neuropathol 113:33~43
Cybulsky MI / 1991 / Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis / Science 251:788~791
Kolodgie FD / 2001 / The thin-cap fibroatheroma: A type of vulnerable plaque: The major precursor lesion to acute coronary syndromes / Curr Opin Cardiol 16:285~292
Drechsler M / 2010 / Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis / Circulation 122:1837~1845
Larionov S / 2007 / Expression of alpha2-macroglobulin, neutrophil elastase, and interleukin-1alpha differs in early-stage and late-stage atherosclerotic lesions in the arteries of the circle of Willis / Acta Neuropathol 113:33~43
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