Adult Neurogenesis and Gliogenesis: Possible Mechanisms for Neurorestoration

Zoltán Rusznák; YuHong Fu; Willem Henskens; Emma Schofield; Woojin S. Kim

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자료유형: 학술저널

저자정보: Zoltán Rusznák (Neuroscience Research Australia) YuHong Fu (Neuroscience Research Australia) Willem Henskens (Neuroscience Research Australia) Emma Schofield (Neuroscience Research Australia) Woojin S. Kim (Neuroscience Research Australia)

저널정보: 한국뇌신경과학회 Experimental Neurobiology Experimental Neurobiology Vol.25 No.3

발행연도: 2016.1

수록면: 103 - 112 (10page)

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연구주제

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연구배경

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연구방법

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The subgranular zone (SGZ) and subventricular zone (SVZ) are developmental remnants of the germinal regions of the brain, hence they retain the ability to generate neuronal progenitor cells in adult life. Neurogenesis in adult brain has an adaptive function because newly produced neurons can integrate into and modify existing neuronal circuits. In contrast to the SGZ and SVZ, other brain regions have a lower capacity to produce new neurons, and this usually occurs via parenchymal and periventricular cell genesis. Compared to neurogenesis, gliogenesis occurs more prevalently in the adult mammalian brain. Under certain circumstances, interaction occurs between neurogenesis and gliogenesis, facilitating glial cells to transform into neuronal lineage. Therefore, modulating the balance between neurogenesis and gliogenesis may present a new perspective for neurorestoration, especially in diseases associated with altered neurogenesis and/or gliogenesis, cell loss, or disturbed homeostasis of cellular constitution. The present review discusses important neuroanatomical features of adult neurogenesis and gliogenesis, aiming to explore how these processes could be modulated toward functional repair of the adult brain.

참고문헌 (107)

참고문헌 신청

Bergmann O / 2013 / Neuroscience. Why adults need new brain cells / Science 340:695~696

Braun SM / 2014 / Adult neurogenesis:mechanisms and functional significance / Development 141:1983~1986

Winner B / 2015 / Adult neurogenesis in neurodegenerative diseases / Cold Spring Harb Perspect Biol 7:a021287

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Marxreiter F / 2013 / Adult neurogenesis in Parkinson's disease / Cell Mol Life Sci 70:459~473

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