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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective：The purpose of the study was to compare cortical amyloid deposition using 18F-florbetaben and positron emission tomography (PET) in healthy controls and subjects with amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD). Methods：We investigated 25 patients : 10 age-matched healthy controls, 10 patients with aMCI and 5 with AD. All participants underwent PET after intravenous injection of 300 MBq of 18F-florbetaben. The 90 min post-injection brain PET data were analysed using statistical parametric mapping. Results：When compared to healthy controls, amyloid deposition was significantly higher in frontal lobe medial frontal gyrus, limbic lobe posterior cingulate, parietal lobe precuneus, sub-loba insula, temporal lobe superior temporal gyrus, parietal lobe inferior parietal lobule, temporal lobe middle temporal gyrus, parietal lobe supramarginal gyrus, occipital lobe middle temporal gyrus of patient group (family wise error correction p<0.05). Conclusion：These results indicate 18F-florbetaben to be an efficacious β-amyloid-targeted tracer. Subjects with aMCI, AD could be easily differentiated from healthy controls by assessment of the PET data.
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참고문헌 (23)
참고문헌 신청
Suk SH / 2000 / Usefulness of occipital EEG spectral profile in the differential diagnosis of Alzheimer type and vascular dementia / J Korean Neurol Assoc 18:292~297
Banerjee S / 2009 / Clinical and cost effectiveness of services for early diagnosis and intervention in dementia / Int J Geriatr Psychiatry 24:748~754
Richards D / 2014 / Florbetaben for PET imaging of betaamyloid plaques in the brain / Neurol Ther 3:79~88
Huang KL / 2013 / Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population / PLoS One 8:e58974
McKhann G / 1984 / Clinical diagnosis of Alzheimer’s disease: report of the NINCDSADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease / Neurology 34:939~944
Banerjee S / 2009 / Clinical and cost effectiveness of services for early diagnosis and intervention in dementia / Int J Geriatr Psychiatry 24:748~754
Richards D / 2014 / Florbetaben for PET imaging of betaamyloid plaques in the brain / Neurol Ther 3:79~88
Huang KL / 2013 / Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population / PLoS One 8:e58974
McKhann G / 1984 / Clinical diagnosis of Alzheimer’s disease: report of the NINCDSADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease / Neurology 34:939~944
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