지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 372 - 380 (9page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaWe hypothesize that the amplitude of low-frequency fluctuations (ALFF) is involved in the altered regional baseline brain function in social anxiety disorder (SAD). The aim of the study was to analyze the altered baseline brain activity in drug-naive adult patients with SAD.
MethodsaaWe investigated spontaneous and baseline brain activities by obtaining the resting-state functional magnetic resonance imaging data of 20 drug-naïve adult SAD patients and 19 healthy controls. Voxels were used to analyze the ALFF values using one- and two-sample t-tests. A post-hoc correlation of clinical symptoms was also performed.
ResultsaaOur findings show decreased ALFF in the bilateral insula, left medial superior frontal gyrus, left precuneus, left middle temporal gyrus, right middle temporal pole, and left fusiform gyrus of the SAD group. The SAD patients exhibited significantly increased ALFF in the right inferior temporal gyrus, right middle temporal gyrus, bilateral middle occipital gyrus, orbital superior frontal gyrus, right fusiform gyrus, right medial superior frontal gyrus, and left parahippocampal gyrus. Moreover, the Liebowitz Social Anxiety Scale results for the SAD patients were positively correlated with the mean Z values of the right middle occipital and right inferior occipital but showed a negative correlation with the mean Z values of the right superior temporal gyrus and right medial superior frontal gyrus.
ConclusionaaThese results of the altered regional baseline brain function in SAD suggest that the regions with abnormal spontaneous activities are involved in the underlying pathophysiology of SAD patients.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Grey SJ / 2000 / Reduction of anxiety during MR imaging: a controlled trial / Magn Reson Imaging 18:351~355
Phan KL / 2003 / Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal: a fMRI study / Bio Psychiatry 53:211~215
Stein MB / 2007 / Increased amygdala and insula activation during emotion processing in anxiety-prone subjects / Am J Psychiatry 164:318~327
Garavan H / 1999 / Right hemispheric dominance of inhibitory control: an event-related functional MRI study / Proc Natl Acad Sci U S A 96:8301~8306
Brune M / 2006 / Theory of mind--evolution, ontogeny, brain mechanisms and psychopathology / Neurosci Biobehav Rev 30:437~455
Phan KL / 2003 / Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal: a fMRI study / Bio Psychiatry 53:211~215
Stein MB / 2007 / Increased amygdala and insula activation during emotion processing in anxiety-prone subjects / Am J Psychiatry 164:318~327
Garavan H / 1999 / Right hemispheric dominance of inhibitory control: an event-related functional MRI study / Proc Natl Acad Sci U S A 96:8301~8306
Brune M / 2006 / Theory of mind--evolution, ontogeny, brain mechanisms and psychopathology / Neurosci Biobehav Rev 30:437~455
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