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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제19권 제1호
- 발행연도
- 2015.1
- 수록면
- 10 - 18 (9page)
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초록· 키워드
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Background and Purpose: The association between the low emotional regulation and the structural change of major depressive disorder (MDD)’s brain has been proposed, and the VBM study on female MDD is still rare. The purposes of the present study are to show the regional volume changes of gray matter (GM) in the cortical and sub cortical structures of the female patients with MDD by optimized voxel-based morphometry (VBM). Methods: Twenty female MDD patients and age, sex matched 21 normal controls were included for the VBM analysis. To identify the change of regional gray matter volume (GMV), the optimized VBM was performed with T1 MRIs. The amounts of gray/white matter and intracranial cavity volumes (ICV) were measured. The analysis of covariance (ANCOVA) and partial correlation analyses covariate with age and ICV were applied for VBM. Results: The age and ICV distributions were similar between the two groups. In the ANCOVA, the total GMV of MDD was smaller than that of normal controls. In the VBM, regional GMV was relatively decreased in the limbic system (amygdalae, ambient gyri, hippocampi heads, subiculum, posterior parahippocampal gyri, pulvinar nuclei, dorsal posterior cingulate gyri, and left pregenual cingulate gyrus. The lingual gyri, short insular gyri, right fusiform gyrus, and right inferior frontal gyrus were also showed decreased regional GMV. Conclusion: The results of this study indicate that the female MDD is mainly associated with the structural deficits of the limbic system and limbic system related cortices, which were known to the center of emotions.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Ashburner J / 2000 / Voxel-based morphometry - the methods / Neuroimage 11 : 805 ~ 821
Beck AT / 1961 / An inventory for measuring depression / Arch Gen Psychiatry 4 : 561 ~ 571
Belmaker RH / 2008 / Major depressive disorder / N Engl J Med 358 : 55 ~ 68
Botteron KN / 2002 / Volumetric reduction in left subgenual prefrontal cortex in early onset depression / Biol Psychiatry 51 : 342 ~ 344
Campbell S / 2006 / An update on regional brain volume differences associated with mood disorders / Curr Opin Psychiatry 19 : 25 ~ 33
Beck AT / 1961 / An inventory for measuring depression / Arch Gen Psychiatry 4 : 561 ~ 571
Belmaker RH / 2008 / Major depressive disorder / N Engl J Med 358 : 55 ~ 68
Botteron KN / 2002 / Volumetric reduction in left subgenual prefrontal cortex in early onset depression / Biol Psychiatry 51 : 342 ~ 344
Campbell S / 2006 / An update on regional brain volume differences associated with mood disorders / Curr Opin Psychiatry 19 : 25 ~ 33
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