지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 227 - 234 (8page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaEvidence of the brain network involved in cognitive dysfunction has been inconsistent for major depressive disorder (MDD), especially during early stage of MDD. This study seeks to examine abnormal cognition connectivity network (CCN) in MDD within the whole brain.
MethodsaaSixteen patients with MDD and 16 health controls were scanned during resting-state using 3.0 T functional magnetic resonance imaging (fMRI). All patients were first episode without any history of antidepressant treatment. Both the left and right dorsolateral prefrontal cortex (DLPFC) were used as individual seeds to identify CCN by the seed-target correlation analysis. Two sample t test was used to calculate between-group differences in CCN using fisher z-transformed correlation maps.
ResultsaaThe CCN was constructed by bilateral seed DLPFC in two groups separately. Depressed subjects exhibited significantly increased functional connectivity (FC) by left DLPFC in one cluster, overlapping middle frontal gyrus, BA7, BA43, precuneus, BA6, BA40, superior temporal gyrus, BA22, inferior parietal lobule, precentral gyrus, BA4 and cingulate gyrus in left cerebrum. Health controls did not show any cluster with significantly greater FC compared to depressed subjects in left DLPFC network. There was no significant difference of FC in right DLPFC network between depressed subjects and the health controls.
ConclusionaaThere are differences in CCN during early stage of MDD, as identified by increased FCs among part of frontal gyrus, parietal cortex, cingulate cortex, and BA43, BA22, BA4 with left DLPFC. These brain areas might be involved in the underlying mechanisms of cognitive dysfunction in MDD.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Alexopoulos GS / 2012 / Functional connectivity in the cognitive control network and the default mode network in late-life depression / J Affect Disord 139:56~65
Lim DW / 2008 / Cerebral lateralization index based on intensity of bold signal of FMRI / Int J Neurosci 118:1628~1642
Vadikolias KM / 2007 / Evaluation of the stability of blood flow over time in the dominant hemisphere: a functional transcranial Doppler study / J Cereb Blood Flow Metab 27:1870~1877
Peeters R / 2009 / The representation of tool use in humans and monkeys: common and uniquely human features / J Neurosci 29:11523~11539
Radua J / 2010 / Neural response to specific components of fearful faces in healthy and schizophrenic adults / Neuroimage 49:939~946
Lim DW / 2008 / Cerebral lateralization index based on intensity of bold signal of FMRI / Int J Neurosci 118:1628~1642
Vadikolias KM / 2007 / Evaluation of the stability of blood flow over time in the dominant hemisphere: a functional transcranial Doppler study / J Cereb Blood Flow Metab 27:1870~1877
Peeters R / 2009 / The representation of tool use in humans and monkeys: common and uniquely human features / J Neurosci 29:11523~11539
Radua J / 2010 / Neural response to specific components of fearful faces in healthy and schizophrenic adults / Neuroimage 49:939~946
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