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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 1,025 - 1,033 (9page)
- DOI
- 10.30773/pi.2021.0099
이용수
초록· 키워드
오류제보하기
Objective Advances in surface-based morphometric methods have allowed researchers to separate cortical volume into cortical thickness (CTh) and surface area (SA). Although CTh alterations in major depressive disorder (MDD) have been observed in numerous studies, few studies have described significant SA alterations. Our study aimed to measure patients’ SAs and to compare it with their CTh to examine whether SA exhibits alteration patterns that differ from those of CTh in drug-naive patients with MDD.Methods A total of 71 drug-naive MDD patients and 111 healthy controls underwent structural magnetic resonance imaging, and SA and CTh were analyzed between the groups.Results We found a smaller SA in the left superior occipital gyrus (L-SOG) in drug-naive patients with MDD. In the CTh analysis, the bilateral fusiform gyrus, left middle occipital gyrus, left temporal superior gyrus, and right posterior cingulate showed thinner cortices in patients with MDD, while the CTh of the bilateral SOG, right straight gyrus, right posterior cingulate, and left lingual gyrus were increased.Conclusion Compared with the bilateral occipito-temporal changes in CTh, SA alterations in patients with MDD were confined to the L-SOG. These findings may improve our understanding of the neurobiological mechanisms of SA alteration in relation to MDD.
목차
등록된 정보가 없습니다.
참고문헌 (87)
참고문헌 신청
GBD 2017 Disease and Injury Incidence and Prevalence Collaborators / 2018 / Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 / Lancet Lond Engl 392:1789~1858
Qiu H / 2018 / Major depressive disorder and magnetic resonance imaging : a mini-review of recent progress / Curr Pharm Des 24:2524~2529
Ashburner J / 2001 / Why voxel-based morphometry should be used / Neuroimage 14:1238~1243
Panizzon MS / 2009 / Distinct genetic influences on cortical surface area and cortical thickness / Cereb Cortex 19:2728~2735
Storsve AB / 2014 / Differential longitudinal changes in cortical thickness, surface area and volume across the adult life span : regions of accelerating and decelerating change / J Neurosci Off J Soc Neurosci 34:8488~8498
Qiu H / 2018 / Major depressive disorder and magnetic resonance imaging : a mini-review of recent progress / Curr Pharm Des 24:2524~2529
Ashburner J / 2001 / Why voxel-based morphometry should be used / Neuroimage 14:1238~1243
Panizzon MS / 2009 / Distinct genetic influences on cortical surface area and cortical thickness / Cereb Cortex 19:2728~2735
Storsve AB / 2014 / Differential longitudinal changes in cortical thickness, surface area and volume across the adult life span : regions of accelerating and decelerating change / J Neurosci Off J Soc Neurosci 34:8488~8498
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