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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제1호
- 발행연도
- 2019.1
- 수록면
- 64 - 73 (10page)
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초록· 키워드
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Objective: Positive symptoms, such as delusion and hallucination, commonly include negative emotional content in schizophrenia. We investigated the neural basis implicated during the processing of strong negative emotional words in patients with schizophrenia. Methods: In our study, 35 patients with schizophrenia and 19 healthy controls were recruited, and the participants were asked to passively view the words that contained swearing and neutral content during functional magnetic resonance imaging. Results: Patients with schizophrenia, compared to healthy controls, showed hypoactivation to the swear and neutral words stimuli in the left inferior frontal gyrus, left middle frontal gyrus, and left angular/supramarginal gyrus. More specifically, patients with remitted schizophrenia were found to have greater activation to the stimuli in the left middle/inferior frontal gyrus than patients with active schizophrenia. Furthermore, in the analysis of regions of interests, the left inferior and middle frontal gyrus activity was related to the severity of positive symptoms, including delusion and suspiciousness. Conclusion: Our results suggest that patients with schizophrenia have difficulty in semantic processing and inhibitory control of swear words, and these abnormalities may be connected with the severity of positive symptoms.
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등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Kohler CG / 2010 / Facial emotion perception in schizophrenia : a meta-analytic review / Schizophr Bull 36:1009~1019
Habel U / 2010 / Neural correlates of emotion recognition in schizophrenia / Schizophr Res 122:113~123
Herbener ES / 2008 / Emotional memory in schizophrenia / Schizophr Bull 34:875~887
Lee SK / 2014 / Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia / PLoS One 9:e90792
Strauss GP / 2013 / Emotion regulation abnormalities in schizophrenia : cognitive change strategies fail to decrease the neural response to unpleasant stimuli / Schizophr Bull 39:872~883
Habel U / 2010 / Neural correlates of emotion recognition in schizophrenia / Schizophr Res 122:113~123
Herbener ES / 2008 / Emotional memory in schizophrenia / Schizophr Bull 34:875~887
Lee SK / 2014 / Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia / PLoS One 9:e90792
Strauss GP / 2013 / Emotion regulation abnormalities in schizophrenia : cognitive change strategies fail to decrease the neural response to unpleasant stimuli / Schizophr Bull 39:872~883
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