Effects of Fengliao-Changweikang in Diarrhea-predominant Irritable Bowel Syndrome Rats and Its Mechanism Involving Colonic Motility

Mengdi Jia; Xiaofang Lu; Zhengfang Wang; Luqing Zhao; Shengsheng Zhang

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자료유형: 학술저널

저자정보: Mengdi Jia (Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University China) Xiaofang Lu (Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University China) Zhengfang Wang (Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University China) Luqing Zhao (Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University China) Shengsheng Zhang (Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University China)

저널정보: 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.3

발행연도: 2018.1

수록면: 479 - 489 (11page)

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Background/Aims This study was designed to investigate the effect of Fengliao-Changweikang (FLCWK) in diarrhea-predominant irritable bowel syndrome (IBS-D) rats and explore its underlying mechanisms. Methods IBS-D model rats were induced by neonatal maternal separation (NMS) combined with restraint stress (RS). In in vivo experiments, the model rats were randomly divided into 5 groups: NMS + RS, FLCWK (low dose, middle dose, and high dose), and pinaverium bromide. The normal control (no handling) rats were classified as the NH group. The therapeutic effect of FLCWK was evaluated by fecal characteristics, electromyographic response and abdominal withdrawal reflex scores. In in vitro experiments, the model rats were randomly divided into 2 groups: NMS + RS, FLCWK (middle dose), and no handling rats were used as the NH group. The differences in basic tension and ACh-induced tension of isolated colonic longitudinal smooth muscle strips (CLSMs) among the 3 groups were observed. In addition, different inhibitors (nifedipine, TMB-8, L-NAME, methylene blue, and 4-AP) were pretreated to explore the underlying mechanisms. Results In in vivo experiments, fecal characteristics, electromyographic response, and abdominal withdrawal reflex scores significantly improved in the FLCWK group, compared with the NMS + RS group. In in vitro experiments, the basic tension and ACh-induced tension of CLSMs in IBS-D rats were significantly inhibited by FLCWK. After pre-treatment with different inhibitors, the ACh-induced tension of CLSMs in each group showed no significant difference. Conclusions FLCWK manifested curative effect in IBS-D rats by inhibiting colonic contraction. The underlying mechanisms may be related to regulatory pathway of nitric oxide/cGMP/Ca2+ and specific potassium channels.

참고문헌 (52)

참고문헌 신청

Mearin F / 2016 / Bowel disorders / Gastroenterology 150:1393~1407

Lovell RM / 2012 / Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis / Clin Gastroenterol Hepatol 10:712~721

Xin Y / 2012 / Subtypes of irritable bowel syndrome on Rome III criteria: a multicenter study / J Gastroenterol Hepatol 27:760~765

Singh P / 2015 / Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation / World J Gastroenterol 21:8103~8109

Bellini M / 2014 / Irritable bowel syndrome: a disease still searching for pathogenesis, diagnosis and therapy / World J Gastroenterol 20:8807~8820

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