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논문 기본 정보

자료유형
학술저널
저자정보
Meng-juan Lin (Department of Gastroenterology Renmin Hospital of Wuhan University) Bao-ping Yu (Key Laboratory of Hubei Province for Digestive System Diseases)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.4
발행연도
2018.1
수록면
643 - 655 (13page)

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Background/Aims Irritable bowel syndrome (IBS) is a common disease characterized by intestinal dysmotility, the mechanism of which remains elusive. We aim to determine whether the high-affinity choline transporter 1 (CHT1), a determinant of cholinergic signaling capacity, modulates intestinal motility associated with stress-induced IBS. Methods A rat IBS model was established using chronic water avoidance stress (WAS). Colonic pathological alterations were evaluated histologically and intestinal motility was assessed by intestinal transit time and fecal water content (FWC). Visceral sensitivity was determined by visceromotor response to colorectal distension. RT-PCR, western blotting, and immunostaining were performed to identify colonic CHT1 expression. Contractility of colonic muscle strips was measured using isometric transducers. enzyme-linked immunosorbent assay was used to measure acetylcholine (ACh). We examined the effects of MKC-231, a choline uptake enhancer, on colonic motility. Results After 10 days of WAS, intestinal transit time was decreased and fecal water content increased. Visceromotor response magnitude in WAS rats in response to colorectal distension was significantly enhanced. Protein and mRNA CHT1 levels in the colon were markedly elevated after WAS. The density of CHT1-positive intramuscular interstitial cells of Cajal and myenteric plexus neurons in WAS rats was higher than in controls. Ammonium pyrrolidine dithiocarbamate partly reversed CHT1 upregulation and alleviated colonic hypermotility in WAS rats. Pharmacological enhancement of CHT1 activity by MKC-231 enhanced colonic motility in control rats via upregulation of CHT1 and elevation of ACh production. Conclusion Upregulation of CHT1 in intramuscular interstitial cells of Cajal and myenteric plexus neurons is implicated in chronic stress-induced colonic hypermotility by modulation of ACh synthesis via nuclear factor-kappa B signaling.

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참고문헌 (6)

참고문헌 신청
Tadayuki Oshima / 2015 / Epidemiology of Functional Gastrointestinal Disorders in Japan and in the World / Journal of Neurogastroenterology and Motility (JNM) 21(3):320~329 Crossref Yajima T / 2011 / Non-neuronal release of ACh plays a key role in secretory response to luminal propionate in rat colon / J Physiol 589(pt 4):953~962 google schola Shan Li / 2016 / Changes in Enteric Neurons of Small Intestine in a Rat Model of Irritable Bowel Syndrome with Diarrhea / Journal of Neurogastroenterology and Motility (JNM) 22(2):310~320 dbpia Zhu MH / 2011 / Muscarinic activation of Ca2+- activated Cl- current in interstitial cells of Cajal / J Physiol 589(Pt 18):4565~4582 google schola Jian-Min T / 2015 / Tashinone II A-sulfoacid-natrum elevates the pain threshold through inhibiting nuclear factor kappa B pathway in neuropathic cancer pain / Indian J Cancer 52(suppl 3):E179~E181 google schola

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