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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.4
- 발행연도
- 2018.1
- 수록면
- 614 - 627 (14page)
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초록· 키워드
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Background/Aims Although functional abdominal pain disorders (FAPDs) are common in children, the accurate pathogenesis of FAPDs is not known yet. Micro-inflammation, particularly tissue eosinophilia of gastrointestinal (GI) tract, has been suggested as the pathophysiology observed in several GI disorders. We aimed to evaluate eosinophilic infiltration throughout the entire GI tract in children with FAPDs, compared to those with inflammatory bowel diseases (IBD) and to normal reference values. Methods We included 56 children with FAPDs, 52 children with Crohn’s disease, and 23 children with ulcerative colitis. All subjects underwent esophagogastroduodenoscopic and colonoscopic examination with biopsies. Tissue eosinophil counts were assessed in 10 regions throughout the GI tract. Results Eosinophil counts of the gastric antrum, duodenum, terminal ileum, cecum, and ascending colon were significantly higher in children with FAPDs compared to normal reference values. Eosinophil counts of the stomach and the entire colon were observed to be significantly higher in children with IBD than in those with FAPDs. Even after selecting macroscopically uninvolved GI segments on endoscopy in children with IBD, eosinophil counts of the gastric body, cecum, descending colon, sigmoid colon, and the rectum were also significantly higher in children with IBD than those with FAPDs. Conclusions Significantly high eosinophil counts of the stomach and colon were observed in the order of IBD, followed by FAPDs, and normal controls, regardless of endoscopically detected macroscopic IBD lesions in children. This suggests some contribution of GI tract eosinophils in the intrinsic pathogenesis of FAPDs in children.
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참고문헌 (4)
참고문헌 신청
Max J Schmulson / 2017 / What Is New in Rome IV / Journal of Neurogastroenterology and Motility (JNM) 23(2):151~163
Eun Hye Lee / 2016 / Analysis of Gastric and Duodenal Eosinophils in Children with Abdominal Pain Related Functional Gastrointestinal Disorders According to Rome III Criteria / Journal of Neurogastroenterology and Motility (JNM) 22(3):459~469
Yantiss RK / 2015 / Eosinophils in the GI tract: how many is too many and what do they mean / Mod Pathol 28(suppl 1):S7~S21
이광재 / 2010 / Duodenal Implications in the Pathophysiology of Functional Dyspepsia / Journal of Neurogastroenterology and Motility (JNM) 16(3):251~257
Eun Hye Lee / 2016 / Analysis of Gastric and Duodenal Eosinophils in Children with Abdominal Pain Related Functional Gastrointestinal Disorders According to Rome III Criteria / Journal of Neurogastroenterology and Motility (JNM) 22(3):459~469
Yantiss RK / 2015 / Eosinophils in the GI tract: how many is too many and what do they mean / Mod Pathol 28(suppl 1):S7~S21
이광재 / 2010 / Duodenal Implications in the Pathophysiology of Functional Dyspepsia / Journal of Neurogastroenterology and Motility (JNM) 16(3):251~257
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