Comparison of survival outcomes after recurrence detected by cancer antigen 125 elevation versus imaging study in epithelial ovarian cancer

백이선; 김태중; 이유영; 최철훈; 이정원; 김병기; 배덕수

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자료유형: 학술저널

저자정보: 백이선 (성균관대학교) 김태중 (삼성서울병원) 이유영 (삼성서울병원) 최철훈 (삼성서울병원) 이정원 (삼성서울병원) 김병기 (성균관대학교) 배덕수 (삼성서울병원)

저널정보: 대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.27 No.5

발행연도: 2016.1

수록면: 1 - 10 (10page)

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Objective: The aim of this study was to compare survival outcomes in two groups of patients withrecurrent epithelial ovarian cancer (EOC) with initial recurrence detection by cancer antigen 125(CA-125) elevation or imaging, and underwent secondary cytoreductive surgery (SCS). Methods: A retrospective review of the medical records was performed on 99 recurrent EOCpatients who underwent SCS at the Samsung Medical Center between January 2002 andDecember 2013. For follow-up after primary treatment, patients were routinely assessed byCA-125 levels every 3 months and computed tomography (CT) scan (or magnetic resonanceimaging [MRI]) every 6 months for first 3 years, and by CA-125 every 6 months and CT scan(or MRI) every 12 months thereafter. Results: The first recurrence was initially identified by either CA-125 elevation (n=41, 41.4%)or by imaging study (n=58, 58.6%). None of the patients showed the symptoms as initialsign of recurrence. There were higher percentages of extra-pelvic recurrence (87.8%) andmultiple recurrences (78.0%) in the group diagnosed by CA-125 elevation. The proportion ofno residual disease after SCS was comparably lower in the CA-125 group (22.0% vs. 72.4%). There were 19 cancer-associated deaths (19.2%) within a median follow-up period of 67months. The group diagnosed by imaging had better overall survival from initial diagnosis(OS1), overall survival after SCS (OS2), progression-free survival after the initial treatment(PFS1) and progression-free survival after SCS compared to those of the CA-125 group (PFS2). Conclusion: EOC patients with recurrence initially detected by imaging study showed bettersurvival outcomes than patients diagnosed by CA-125 elevation.

참고문헌 (26)

참고문헌 신청

Siegel RL / 2015 / Cancer statistics, 2015 / CA Cancer J Clin 65:5~29

임명철 / 2013 / Incidence of cervical, endometrial, and ovarian cancer in Korea, 1999-2010 / Journal of Gynecologic Oncology 24(4):298~302

Cannistra SA / 2004 / Cancer of the ovary / N Engl J Med 351:2519~2529

Vaidya AP / 2003 / The follow-up of ovarian cancer / Semin Oncol 30:401~412

Rubin SC / 1999 / Ten-year follow-up of ovarian cancer patients after second-look laparotomy with negative findings / Obstet Gynecol 93:21~24

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백이선

소속기관 성균관의대 산부인과

주요연구분야 의약학 > 임상의학 > 산부인과학

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