지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 14 (14page)
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Objective: Adjuvant chemotherapy was introduced in patients with early-stage ovarian cancer (OC). The benefit of standard chemotherapeutic regimens including taxane has not been established. Methods: Patients with early-stage OC from the National Health Insurance Research database of Taiwan who received platinum plus cyclophosphamide (CP) or platinum plus paclitaxel (PT) for 3–6 cycles were recruited, and the disease-free survival (DFS) and overall survival (OS) were determined. Results: A total of 1,510 early-stage OC patients, including 841 who received CP regimen and 699 who received PT regimen, were included. The 2 groups had a similar estimated probability of 5-year DFS (PT vs. CP, 79.0% vs. 77.6%; p=0.410) and OS (84.6% vs. 84.3%; p=0.691). Patients >50 years of age who received the CP regimen had a lower 5-year DFS than the patients ≤50 years of age who received the CP (p<0.001) or PT regimens (p=0.001). Additionally, patients >50 years of age who received the CP regimen had a worse 5-year OS compared with the other 3 groups (p=0.019) (p=0.179 for patients >50 years of age in the PT group; p=0.002 for patients ≤50 years of age in the CP group; and p=0.061 for patients ≤50 years of age in the PT group). Patients with the CP or PT regimen for 3–5 cycles had a similar 5-year DFS and OS compared to 6 cycles (p>0.050). Conclusion: Chemotherapeutic regimens with taxane could be recommended for early-stage OC patients >50 years of age.
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참고문헌 (40)
참고문헌 신청
Ying-Cheng Chiang / 2013 / Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan / Journal of Gynecologic Oncology 24(4):342~351
Bell J / 2006 / Randomized phase III trial of three versus six cycles of adjuvant carboplatin and paclitaxel in early stage epithelial ovarian carcinoma: a Gynecologic Oncology Group study / Gynecol Oncol 102:432~439
Young RC / 1990 / Adjuvant therapy in stage I and stage II epithelial ovarian cancer. Results of two prospective randomized trials / N Engl J Med 322:1021~1027
Vergote IB / 1992 / Randomized trial comparing cisplatin with radioactive phosphorus or whole-abdomen irradiation as adjuvant treatment of ovarian cancer / Cancer 69:741~749
Ahmed FY / 1996 / Natural history and prognosis of untreated stage I epithelial ovarian carcinoma / J Clin Oncol 14:2968~2975
Bell J / 2006 / Randomized phase III trial of three versus six cycles of adjuvant carboplatin and paclitaxel in early stage epithelial ovarian carcinoma: a Gynecologic Oncology Group study / Gynecol Oncol 102:432~439
Young RC / 1990 / Adjuvant therapy in stage I and stage II epithelial ovarian cancer. Results of two prospective randomized trials / N Engl J Med 322:1021~1027
Vergote IB / 1992 / Randomized trial comparing cisplatin with radioactive phosphorus or whole-abdomen irradiation as adjuvant treatment of ovarian cancer / Cancer 69:741~749
Ahmed FY / 1996 / Natural history and prognosis of untreated stage I epithelial ovarian carcinoma / J Clin Oncol 14:2968~2975
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