지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Human papillomavirus (HPV) genotypes that infect the genital tract play a main etiologic role in cervical cancer progression. Other environmental factors, such as sexually transmitted diseases and the host genetic pattern, contribute to infection persistence of the uterus and cervical epithelium in sustaining their malignancy. The Janus kinase 2 is a non-receptor tyrosine kinase in cell signaling process of tumor genesis. In the present study, JAK2 V167F mutation was distinguished in women with sexually transmitted infections, such as Herpes simplex virus 2, Chlamydia trachomatis and Mycoplasma genitalium and cervical cancer. Methods: This case-control survey was performed on 195 liquid based cytology of women specimens. Fifty, 98, and 47 samples were from women with known cervical cancer, HPV positive and HPV negative, respectively. Single nucleotide polymorphism analysis, sexually transmitted infections detection and HPV genotyping were carried out using approved PCR- RFLP, in-house multiplex TaqMan Real Time PCR and the reverse dot blot hybridization assay. Results: HPVs 6, 16, 18, 11, 31, and 51 were the most common genotypes. The prevalence rate of multiple HPV genotypes was 46.0% to 10.1%. Analysis of JAK2 V617F (1849 G ＞ T) showed that prevalence of mutation was GG (65.1%), GA (34.9%), and TT (0%), respectively. There were no statistically significant differences between this mutation and variables of population survey (P ≥ 0.05). Conclusions: The molecular epidemiology study on the genetic polymorphisms, i.e., JAK2 V617F and other single nucleotide polymorphisms as a diagnostic tool is necessary for cancer screening and prophylactic programs.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Husain RS / 2015 / Global variation of human papillomavirus genotypes and selected genes involved in cervical malignancies / Ann Glob Health 81:675~683
Mboumba-Bouassa RS / 2017 / Cervical cancer in sub-Saharan Africa: an emerging and preventable disease associated with oncogenic human papillomavirus / Med Sante Trop 27:16~22
Shi N / 2017 / Analysis of risk factors for persistent infection of asymptomatic women with high-risk human papilloma virus / Hum Vaccin Immunother 13:1~7
Mittal S / 2017 / Risk of high-grade precancerous lesions and invasive cancers in high-risk HPV-positive women with normal cervix or CIN 1 at baseline-A population-based cohort study / Int J Cancer 140:1850~1859
Shayanfar N / 2013 / Detection of mucosal type human papillomavirus in cutaneous squamous cell carcinoma in Iran / Pathol Res Pract 209:90~94
Mboumba-Bouassa RS / 2017 / Cervical cancer in sub-Saharan Africa: an emerging and preventable disease associated with oncogenic human papillomavirus / Med Sante Trop 27:16~22
Shi N / 2017 / Analysis of risk factors for persistent infection of asymptomatic women with high-risk human papilloma virus / Hum Vaccin Immunother 13:1~7
Mittal S / 2017 / Risk of high-grade precancerous lesions and invasive cancers in high-risk HPV-positive women with normal cervix or CIN 1 at baseline-A population-based cohort study / Int J Cancer 140:1850~1859
Shayanfar N / 2013 / Detection of mucosal type human papillomavirus in cutaneous squamous cell carcinoma in Iran / Pathol Res Pract 209:90~94
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