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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.1
- 수록면
- 53 - 57 (5page)
- DOI
- 10.47429/lmo.2022.12.1.53
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초록· 키워드
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Although the JAK2 V617F mutation is a common genetic basis for the BCR-ABL1-negative myeloproliferative neoplasm (MPN), it is very rarely observed in acute myeloid leukemia (AML) without antecedent MPN. While JAK2 V617F has a well-defined role as a driver mutation in MPNs, its role in de novo AML remains elusive. Here, we retrospectively identified two patients with JAK2 V617F-positive AML by next-generation sequencing. These patients were diagnosed with AML without a history of an antecedent MPN. The presence of dysmegakaryopoiesis and a non-complex karyotype were consistent with the features reported in previous cases. Concurrent mutations in JAK2 and MPL were identified in one of the patients. Presence of the JAK2 V617F mutation in AML does not imply a blast phase of an occult MPN and suggests a separate clinical entity.
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