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논문 기본 정보

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저자정보
Shinichiro Shinzaki (Osaka University Graduate School of Medicine) Toshimitsu Fujii (Tokyo Medical and Dental University) Shigeki Bamba (Shiga University of Medical Science) Maiko Ogawa (The Jikei University School of Medicine Katsushika Medical Center) Taku Kobayashi (Kitasato University Kitasato Institute Hospital) Masahide Oshita (Osaka Police Hospital) Hiroki Tanaka (Sapporo Kosei General Hospital) Keiji Ozeki (Nagoya City University Graduate School of Medical Sciences) Sakuma Takahashi (Kagawa Prefectural Central Hospital) Hiroki Kitamoto (Kobe City Medical Center General Hospital) Kazuhito Kani (Saitama Medical Center) Sohachi Nanjo (Graduate School of Medicine and Pharmaceutical Sciences University of Toyama) Takeshi Sugaya (Dokkyo Medical University) Yuko Sakakibara (National Hospital Organization Osaka National Hospital) Toshihiro Inokuchi (Okayama University Graduate School of Medicine) Kazuki Kakimoto (Osaka Medical College) Akihiro Yamada (Toho University Sakura Medical Center) Hisae Yasuhara (Mitoyo General Hospital) Yoko Yokoyama (Hyogo College of Medicine) Takuya Yoshino (Kitano Hospital) Akira Matsui (Toranomon Hospital) Misaki Nakamura (Mie University Graduate School of Medicine) Taku Tomizawa (Gunma University) Ryosuke Sakemi (Tobata Kyoritsu Hospital) Noriko Kamata (Osaka City University Graduate School of Medicine) Toshifumi Hibi (Kitasato University Kitasato Institute Hospital)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.16 No.4
발행연도
2018.1
수록면
609 - 618 (10page)

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Background/Aims: The influences of Helicobacter pylori eradication therapy on the disease course of inflammatory bowel disease (IBD) are still unclear. We therefore conducted a multicenter, retrospective cohort study to evaluate the safety of H. pylori eradication therapy for IBD patients. Methods: IBD patients with H. pylori eradication from 2005 to 2015 (eradication group) and control patients (non-eradication group; 2 paired IBD patients without H. pylori eradication matched with each eradicated patient) were included. IBD exacerbation (increased/additional IBD drug or IBD-associated hospitalization/surgery) and disease improvement based on the physicians’ global assessment were investigated at baseline, and at 2 and 6 months after eradication or observation. Results: A total of 429 IBD (378 ulcerative colitis, 51 Crohn’s disease) patients, comprising 144 patients in the eradication group and 285 patients in the non-eradication group, were enrolled at 25 institutions. IBD exacerbation was comparable between groups (eradication group: 8.3% at 2 months [odds ratio, 1.76; 95% confidence interval, 0.78–3.92; P=0.170], 11.8% at 6 months [odds ratio, 1.60; 95% confidence interval, 0.81–3.11; P=0.172]). Based on the physicians’ global assessment at 2 months, none of the patients in the eradication group improved, whereas 3.2% of the patients in the non-eradication group improved (P=0.019). Multivariate analysis revealed that active disease at baseline, but not H. pylori eradication, was an independent factor for IBD exacerbation during 2 months’ observation period. The overall eradication rate was 84.0%–comparable to previous reports in non-IBD patients. Conclusions: H. pylori eradication therapy does not alter the short-term disease activity of IBD. (Intest Res 2018;16:609-618)

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참고문헌 (3)

참고문헌 신청
Hiroko Nagao-Kitamoto / 2016 / Pathogenic role of the gut microbiota in gastrointestinal diseases / Intestinal research 14(2):127~138 dbpia Silverberg MS / 2005 / Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology / Can J Gastroenterol 19(Suppl A):5A~36A Crossref Sustmann A / 2016 / Helicobacter pylori in children / Helicobacter 21(Suppl 1):49~54 Crossref

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