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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 173 - 177 (5page)
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초록· 키워드
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Melanoma is one of the most aggressive cancers in the world and is responsible for the majority of skin cancer deaths. Recent advances in the field of immunotherapy using active, adoptive, and antigen-specific therapeutic approaches, have generated the expectation that these technologies have the potential to improve the treatment of advanced malignancies, including melanoma. Treatment options for metastatic melanoma patients have been dramatically improved by the FDA approval of new therapeutic agents including vemurafenib, dabrafenib, and sorafenib. These kinase inhibitors have the potential to work in tandem with MEK, PI3K/AKT, and mTOR to inhibit the activity of melanoma inducing BRAF mutations. This review summarizes the effects of the new therapeutic agents against melanoma and the underlying biology of these BRAF inhibitors.
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등록된 정보가 없습니다.
참고문헌 (47)
참고문헌 신청
Ahn A / 2017 / The slow cycling phenotype : a growing problem for treatment resistance in melanoma / Mol Cancer Ther 16:1002~1009
Davies H / 2002 / Mutations of the BRAF gene in human cancer / Nature 417:949~954
Platz A / 2008 / Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site / Mol Oncol 1:395~405
Wellbrock C / 2016 / The complexity of the ERK/MAP-Kinase pathway and the treatment of melanoma skin cancer / Front Cell Dev Biol 4:33
Fiskus W / 2016 / B-Raf Inhibition in the Clinic : Present and Future / Annu Rev Med 67:29~43
Davies H / 2002 / Mutations of the BRAF gene in human cancer / Nature 417:949~954
Platz A / 2008 / Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site / Mol Oncol 1:395~405
Wellbrock C / 2016 / The complexity of the ERK/MAP-Kinase pathway and the treatment of melanoma skin cancer / Front Cell Dev Biol 4:33
Fiskus W / 2016 / B-Raf Inhibition in the Clinic : Present and Future / Annu Rev Med 67:29~43
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