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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 57 - 62 (6page)
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Purpose: The purpose of this study is to compare dosimetric parametersof intensity-modulated mode of TomoDirect and threedimensionalconformal radiotherapy (3D-CRT) in patients withearly breast cancer. Methods: TomoDirect and 3D-CRT planningwere carried out for 26 patients with early breast cancer whohad received breast-conserving surgery. A total of 50.4 Gy in 28fractions were prescribed to the planning target volume. The organsat risk (OAR) such as lung and heart were contoured. Planningtarget volume (PTV) dose coverage, radiation conform-ityindex (RCI), radical dose homogeneity index (rDHI), and irradiationdose of organs at risk were compared between TomoDirectand 3D-CRT planning. Results: The mean PTV dose (51.65±0.37Gy) and V47.8 (100%) in TomoDirect were significantly higher thanthe mean PTV dose (50.88±0.65 Gy) and V47.8 (89.23%±0.06%)in 3D-CRT (all, p<0.001). The RCI value in TomoDirect was significantlybetter than that in 3D-CRT (1.00 vs. 1.13, p<0.001).
However, the rDHI value in TomoDirect was not significantly betterthan that in 3D-CRT (0.72 vs. 0.67, p=0.056). The mean lungdose and V10, V20, V30, and V40 values of ipsilateral lung in Tomo-Direct were significantly lower than those in 3D-CRT (all,p<0.05). There is no significant difference in the V10, V20, V30, andV40 values of heart between TomoDirect and 3D-CRT. And themean dose for heart in TomoDirect was .marginally lower thanthat in 3D-CRT (1.05 Gy vs. 1.62 Gy, p=0.085). The mean dosefor left anterior descending coronary artery in left breast cancerwas significantly lower in TomoDirect than in 3D-CRT (7.2 Gy vs.
12.1 Gy, p<0.001). Conclusion: Compared to 3D-CRT, TomoDirectcould result in favorable target coverage while reducing theirradiation dose of the ipsilateral lung for patients with earlybreast cancer.
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참고문헌 (27)
참고문헌 신청
서민아 / 2013 / Trends in Cancer Screening Rates among Korean Men and Women: Results from the Korean National Cancer Screening Survey, 2004-2012 / Cancer Research and Treatment 45(2):86~94
Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347:1233~1241
Early Breast Cancer Trialists’ Collaborative Group / 2000 / Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer : an overview of the randomised trials / Lancet 355:1757~1770
Early Breast Cancer Trialists’ Collaborative Group / 2011 / Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials / Lancet 378:1707~1716
Franco P / 2014 / Intensity-modulated and hypofractionated simultaneous integrated boost adjuvant breast radiation employing statics ports of tomotherapy(TomoDirect) : a prospective phase II trial / J Cancer Res Clin Oncol 140:167~177
Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347:1233~1241
Early Breast Cancer Trialists’ Collaborative Group / 2000 / Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer : an overview of the randomised trials / Lancet 355:1757~1770
Early Breast Cancer Trialists’ Collaborative Group / 2011 / Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials / Lancet 378:1707~1716
Franco P / 2014 / Intensity-modulated and hypofractionated simultaneous integrated boost adjuvant breast radiation employing statics ports of tomotherapy(TomoDirect) : a prospective phase II trial / J Cancer Res Clin Oncol 140:167~177
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