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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 551 - 558 (8page)
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Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic factors. VEGF plasma levels have been reported to be significantly elevated in the patients with hypertension. This study aims to elucidate the associations of the VEGF -634G[C and 936C[T polymorphisms with the hypertensive patients in Korea. Genotyping of the VEGF polymorphisms was carried out by polymerase chain reaction and endonuclease digestion. The C allele of the VEGF -634G[C polymorphism and T allele of the 936C[T polymorphism were significantly higher in the hypertensive patients than in the normotensive controls. When the data of the genotype were stratified by gender, the association was gender-specific. We also found the associations of the haplotypes, composed of the VEGF -634G[C and 936C[T polymorphisms, with hypertensive group. Dominant models of -634G[C and 936C[T polymorphisms were associated with risk components of hypertension, according to the stratification analysis. Thus, this study demonstrates that the VEGF -634G[C and 936C[T polymorphisms may provide important genetic markers in identifying people at risk for hypertension. So far, association studies of VEGF gene polymorphisms with the hypertensive patients were rare. Therefore, further evaluation is required in other ethnic or racial populations with large samples to confirm our data.
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참고문헌 (30)
참고문헌 신청
Adams J / 2000 / Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen / Cancer Res 60:2898~2905
Akhter Q / 2012 / Polymorphisms in the 3'UTR of the human leptin gene and their role in hypertension / Mol Med Rep 5:1058~1062
Bae SJ / 2008 / Genderspecific association between polymorphism of vascular endothelial growth factor (VEGF 936 C>T) gene and colon cancer in Korea / Anticancer Res 28:1271~1276
Chen CY / 1995 / AU-rich elements: characterization and importantance in mRNA degradation / TIBS 20:465~470
Gargett CE / 2001 / Focal vascular endothelial growth factor correlates with angiogenesis in human endometrium. Role of intravascular neutrophils / Hum Reprod 16:1065~1075
Akhter Q / 2012 / Polymorphisms in the 3'UTR of the human leptin gene and their role in hypertension / Mol Med Rep 5:1058~1062
Bae SJ / 2008 / Genderspecific association between polymorphism of vascular endothelial growth factor (VEGF 936 C>T) gene and colon cancer in Korea / Anticancer Res 28:1271~1276
Chen CY / 1995 / AU-rich elements: characterization and importantance in mRNA degradation / TIBS 20:465~470
Gargett CE / 2001 / Focal vascular endothelial growth factor correlates with angiogenesis in human endometrium. Role of intravascular neutrophils / Hum Reprod 16:1065~1075
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