지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.6
- 수록면
- 659 - 670 (12page)
- DOI
- 10.1007/s13258-022-01246-9
이용수
초록· 키워드
오류제보하기
Background Polymorphisms of endothelial nitric oxide synthases (eNOS) have been associated with cancer susceptibility. Also, metabolic syndrome is associated with cancer malignancy. However, the effect of eNOS polymorphisms and metabolic syndrome on colorectal cancer (CRC) prognosis remains unclear.
Objective To investigated whether three genetic polymorphisms (? 786 T?>?C rs2070744, 4a4b rs869109213, and 894G?>?T rs1799983) in the eNOS and metabolic syndrome (MetS) were associated with CRC patient survival.
Methods We genotyped three polymorphisms of eNOS (? 786 T?>?C, 4a4b, and 894G?>?T) in 312 CRC cases from the Korean population by polymerase chain reaction-restriction fragment length polymorphism (PCR?RFLP) analysis.
Results Although the three eNOS polymorphisms were not causative of MetS, the TT genotype of the 894G?>?T polymorphism was associated with a worse survival rate compared with the GG genotype in the CRC group with MetS than in the CRC group without MetS (5-years survival; adjusted HR?=?54.777; 95% CI 5.073?591.487 and RFS; adjusted HR?=?14.909; 95% CI 1.571?141.528).
Conclusions The eNOS polymorphisms were not associated with metabolic syndrome prevalence in CRC patients. However, our findings suggest that the eNOS 894G?>?T polymorphism with MetS was associated with poor clinical outcomes.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Associations of MTRR and TSER polymorphisms related to folate metabolism with susceptibility to metabolic syndrome
Genes & Genomics
2019 .01
-
Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes
Genes & Genomics
2020 .01
-
Effects of methionine synthase and methionine synthase reductase polymorphisms on hypertension susceptibility
Genes & Genomics
2020 .01
-
The Apolipoprotein A1 polymorphisms were associated with decreased risk for metabolic syndrome in Koreans
Genes & Genomics
2015 .01
-
Association between Nutrient Intake and Metabolic Syndrome in Patients with Colorectal Cancer
Clinical Nutrition Research
2017 .01
-
일부 초등학생의 대표적 신체활동의 에너지소비량 측정 및 에너지소비량과 체중과의 상관성 분석
Journal of Nutrition and Health
2015 .04
-
Whole genome detection of recent selection signatures in Sarabi cattle: a unique Iranian taurine breed
Genes & Genomics
2020 .01
-
Diet, Sleep and Metabolic Syndrome Among a Legal Amazon Population, Brazil
Clinical Nutrition Research
2015 .01
-
Association of COX2 −765G>C promoter polymorphism and coronary artery disease in Korean population
Genes & Genomics
2019 .01
-
Native low density lipoprotein increases the production of both nitric oxide and reactive oxygen species in the human umbilical vein endothelial cells
Genes & Genomics
2019 .01
-
대사증후군에 대한 운동의 과학적인 효과
과학논집
2016 .02
-
한국 성인의 대사증후군 여부와 치료 유무에 따른 식생활 평가 : 2017년 국민건강영양조사 자료 이용
대한지역사회영양학회지
2022 .08
-
Transethnic meta-analysis of exome-wide variants identifies new loci associated with male-specific metabolic syndrome
Genes & Genomics
2022 .05
-
남성 대사증후군 유병률과 관련 요인 분석: 흡연 상태와 신체활동
Korean Journal of Health Promotion
2023 .06
-
Inverse association of improved adherence to dietary guidelines with metabolic syndrome: the Seoul Metabolic Syndrome Management program
Nutrition Research and Practice
2020 .12
-
Inverse association of improved adherence to dietary guidelines with metabolic syndrome: the Seoul Metabolic Syndrome Management program
Nutrition Research and Practice
2020 .12
-
Gender-specific association of polymorphisms in the 50-UTR and 30-UTR of VEGF gene with hypertensive patients
Genes & Genomics
2015 .01
-
일 보건소에서 시행된 대사증후군 관리 프로그램의 효과
경북간호과학지
2016 .08
-
종합검진센터를 내원한 수진자의 대사증후군 여부와 나트륨섭취와의 관련성에 대한 연구
동아시아식생활학회지
2018 .12
-
Anti-cancer Role of Probiotic-derived P8 Protein in Colorectal Cancer
한국미생물학회 학술대회논문집
2022 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0