지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 837 - 844 (8page)
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초록· 키워드
오류제보하기
Purpose: Existing data supports a relationship between pelvic floor dysfunction and lower urinary tract symptoms. We developed a survival model of pelvic floor dysfunction in the rabbit and evaluated cystometric (CMG), electromyographic (EMG) and ambulatory voiding behavior. Materials and Methods: Twelve female adult virgin rabbits were housed in metabolic cages to record voiding and defecation. Anesthetized CMG/EMG was performed before and after treatment animals (n=9) received bilateral tetanizing needle stimulation to the pubococcygeous (PC) muscle and controls (n=3) sham needle placement. After 7 days all animals were subjected to tetanizing transvaginal stimulation and CMG/EMG. After 5 days a final CMG/EMG was performed. Results: Of rabbits that underwent needle stimulation 7 of 9 (78%) demonstrated dysfunctional CMG micturition contractions versus 6 of 12 (50%) after transvaginal stimulation. Needle stimulation of the PC musculature resulted in significant changes in: basal CMG pressure, precontraction pressure change, contraction pressure, interval between contractions and postvoid residual; with time to 3rd contraction increased from 38 to 53 minutes (p=0.008 vs. prestimulation). Vaginal noxious stimulation resulted in significant changes in: basal CMG pressure and interval between contractions; with time to 3rd contraction increased from 37 to 46 minutes (p=0.008 vs. prestimulation). Changes in cage parameters were primarily seen after direct needle stimulation. Conclusions: In a majority of animals, tetanizing electrical stimulation of the rabbit pelvic floor resulted in voiding changes suggestive of pelvic floor dysfunction as characterized by a larger bladder capacity, longer interval between contractions and prolonged contraction duration.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Messelink B / 2005 / Standardization of terminology of pelvic floor muscle function and dysfunction: report from the pelvic floor clinical assessment group of the International Continence Society / Neurourol Urodyn 24:374~380
Ustinova EE / 2010 / Cross-talk and sensitization of bladder afferent nerves / Neurourol Urodyn 29:77~81
Malykhina AP / 2007 / Neural mechanisms of pelvic organ crosssensitization / Neuroscience 149:660~672
Rudick CN / 2007 / Organ cross talk modulates pelvic pain / Am J Physiol Regul Integr Comp Physiol 293:R1191~R1198
Abramowitch SD / 2009 / Tissue mechanics, animal models, and pelvic organ prolapse: a review / Eur J Obstet Gynecol Reprod Biol 144(Suppl 1):S146~S158
Ustinova EE / 2010 / Cross-talk and sensitization of bladder afferent nerves / Neurourol Urodyn 29:77~81
Malykhina AP / 2007 / Neural mechanisms of pelvic organ crosssensitization / Neuroscience 149:660~672
Rudick CN / 2007 / Organ cross talk modulates pelvic pain / Am J Physiol Regul Integr Comp Physiol 293:R1191~R1198
Abramowitch SD / 2009 / Tissue mechanics, animal models, and pelvic organ prolapse: a review / Eur J Obstet Gynecol Reprod Biol 144(Suppl 1):S146~S158
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