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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 46 - 50 (5page)
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초록· 키워드
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BackgroundThe present study is designed to evaluate the reliability and cost effectiveness of celluloseacetate Hb electrophoresis and high performance liquid chromatography (HPLC) in thedetermination of HbA2 levels. MethodsThe test population comprised 160 individuals divided into four groups: normal individuals, β-thalassemia trait (BTT) patients, iron deficiency anemia (IDA) patients, andco-morbid patients (BTT with IDA). HbA2 levels determined using cellulose acetate Hbelectrophoresis and HPLC were compared. ResultsHbA2 levels were found to be diagnostic for classical BTT using either method. In co-morbidcases, both techniques failed to diagnose all cases of BTT. The sensitivity, specificity,and Youden’s index for detection of the co-morbid condition was 69% and 66% for HPLCand cellulose acetate Hb electrophoresis, respectively. ConclusionThis study revealed that semi-automated cellulose acetate Hb electrophoresis is moresuitable for use in β-thalassemia prevention programs in low-income countries likePakistan. This technique is easily available, simple and cost effective.
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참고문헌 (19)
참고문헌 신청
Kim HJ / 2012 / Structure, function, and assembly of heme centers in mitochondrial respiratory complexes / Biochim Biophys Acta 1823:1604~1616
Thom CS / 2013 / Hemoglobin variants: biochemical properties and clinical correlates / Cold Spring Harb Perspect Med 3:a011858
George E / 2011 / Screening for intermediate and severe forms of thalassaemia in discarded red blood cells : optimization and feasibility / Med J Malaysia 66:429~434
Mosca A / 2009 / The role of haemoglobin A(2)testing in the diagnosis of thalassaemias and related haemoglobinopathies / J Clin Pathol 62:13~17
Kunkel HG / 1957 / Observations on the minor basic hemoglobin component in the blood of normal individuals and patients with thalassemia / J Clin Invest 36:1615~1625
Thom CS / 2013 / Hemoglobin variants: biochemical properties and clinical correlates / Cold Spring Harb Perspect Med 3:a011858
George E / 2011 / Screening for intermediate and severe forms of thalassaemia in discarded red blood cells : optimization and feasibility / Med J Malaysia 66:429~434
Mosca A / 2009 / The role of haemoglobin A(2)testing in the diagnosis of thalassaemias and related haemoglobinopathies / J Clin Pathol 62:13~17
Kunkel HG / 1957 / Observations on the minor basic hemoglobin component in the blood of normal individuals and patients with thalassemia / J Clin Invest 36:1615~1625
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