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Objective: To compare quality of life (QoL) and sexual functioning between sexually active ovarian cancer survivors and healthywomen. Methods: A cross-sectional study was performed in 103 successfully treated ovarian cancer survivors and 220 healthy women. All women had engaged in sexual activity within the previous 3 months, and ovarian cancer survivors were under surveillanceafter primary treatment without evidence of disease. QoL and sexual functioning were assessed using three questionnaires; theEuropean Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30), OvarianCancer Module (EORTC QLQ-OV28), and the Female Sexual Function Index (FSFI). Propensity score matching was used to adjustcovariates between the ovarian cancer survivor and healthy women groups. In total, 73 ovarian cancer survivors and 73 healthywomen were compared. Results: Poorer social functioning (mean, 82.4 vs. 90.9; p=0.010) and more financial difficulties (mean, 16.4 vs. 7.8; p=0.019) wereobserved among ovarian cancer survivors than among healthy women. Sexuality, both in terms of desire, arousal, lubrication,orgasm, satisfaction, and pain and in terms of interest in sex, sexual activity, and enjoyment of sex (EORTC QLQ-OV28) weresimilar between the groups. However, vaginal dryness was more problematic in ovarian cancer survivors, with borderlinestatistical significance (p=0.081). Conclusion: Sexuality was not impaired in ovarian cancer survivors who were without evidence of disease after primarytreatment and having sexual activities, compared with healthy women, whereas social functioning and financial status diddeteriorate. Prospective cohort studies are needed.

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