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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.3
- 수록면
- 36 - 40 (5page)
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The CHCl3 fraction of the MeOH extract of Ganoderma gibbosum (Ganodermataceae) exhibited cytotoxic activity on five cancer cell lines (MDA-MB-231, SK-hep1, A549, HCT116, and SNU638). Six highly oxygenated lanostane-type triterpenoids (lanostanoids) were isolated by column chromatography to test cytotoxicity on cancer cells. The five known lanostanoids were identified as gibbosic acids A, B, D, G, and H by comparison of molecular ion peaks with the literature data. The structure of a new lanostanoid, gibbosic acids I, was identified to be 3,8,15,20S-tetrahydroxy-7,12,23-trioxolanost-9(11)-en-26-oic acid on the basis of NMR and MS spectroscopy. The three lanostanoids of gibbosic acids A, H, and I of the six isolates significantly suppressed the growth of cancer cells. In particular, the IC<SUB>50</SUB> of gibbosic acid H was prominently low ranging from 2.64–6.56 μM.
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Abstract
재료 및 방법
결과 및 고찰
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참고문헌 (5)
참고문헌 신청
Pu, D. B. / 2017 / Highly oxygenated lanostane-type tritperpenoids and their bioactivity from the fruiting body of Ganderma gibbosum / Fitoterapia 119:1~7
Chen, H. / 2016 / Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus : A review / Fitoterapia 113:6~26
Yue, Q. X. / 2010 / Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells / Phytomedicine 17:606~613
Yoshikawa, K. / 2002 / New lanostanoids, elfvingic acids A-H, from the fruit body of Elfvingia applanata / J. Nat. Prod 65:548~552
Isaka, M. / 2013 / Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324 / Phytochemistry 87:133~139
Chen, H. / 2016 / Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus : A review / Fitoterapia 113:6~26
Yue, Q. X. / 2010 / Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells / Phytomedicine 17:606~613
Yoshikawa, K. / 2002 / New lanostanoids, elfvingic acids A-H, from the fruit body of Elfvingia applanata / J. Nat. Prod 65:548~552
Isaka, M. / 2013 / Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324 / Phytochemistry 87:133~139
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