Reproductive and developmental toxicity screening test of new TiO₂ GST in Sprague-Dawley rats

Hyung Seon Baek; Myeong Kyu Park; Hye Min Kim; Jae Min Im; Heung Sik Seo; Hee Ju Park; Sung Soon Nah

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자료유형: 학술저널

저자정보: Hyung Seon Baek (Korea Testing and Research Institute (KTR)) Myeong Kyu Park (Korea Testing and Research Institute (KTR)) Hye Min Kim (Korea Testing and Research Institute (KTR)) Jae Min Im (Korea Testing and Research Institute (KTR)) Heung Sik Seo (Korea Testing and Research Institute (KTR)) Hee Ju Park (Bentech Frontier) Sung Soon Nah (Korea Testing & Research Institute)

저널정보: 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.37 No.3

발행연도: 2022.9

수록면: 1 - 16 (16page)

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TiO₂ nanoparticles are widely used in paints, plastics, cosmetics, printing ink, rubber, food products, pharmaceuticals and other products (photocatalyst, etc.). However, there is little toxicological information during reproduction and developmental period. This study was performed to obtain safety data for new TiO₂ powder, GST (Green Sludge Titanium) produced through sludge recycling of the sewage treatment plant for Reproduction/developmental toxicity screening test in Sprague-Dawley (SD) rats in according to the OECD test guideline (TG 421). Based on the results of the dose-range finding study (14-day repeated toxicity), GST was orally administered to rats at doses of 0, 500, 1000, and 2000 mg/kg B.W/day. Males were dosed for 35 days beginning 14 days before mating, and females for a maximum of 53 days beginning 14 days before mating to day 13 of lactation, including throughout the mating, gestation and lactation periods. In the reproductive and developmental examinations, there were no marked toxicities in terms of general clinical signs, body weight, food consumption, organ weights, macroscopic / microscopic findings, stages of spermatogenesis in the testis, reproductive finding (estrous cycle, copulation-fertility-gestation index), developmental finding (number of corpora lutea and implantations, pups parameters including live birth and viability index). The NOAEL for reproductive/developmental screening toxicity was concluded to be 2000 mg/kg/day under the present study conditions.

#TiO₂ #reproduction/developmental toxicity screening test #NOAEL #GST

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