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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.12
- 수록면
- 234 - 239 (6page)
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The number of people suffering from diabetes have been increased around the world. In this study, we investigated the antidiabetic and antioxidant effects of Angelica decursiva (Miq.) Franch. & Sav. and its main compounds. It was divided into root(R) and aerial part(AP) for comparative analysis. Total polyphenol, total flavonoid content was higher in AP extract, but nodakenin content was higher in R(1169.13 ± 6.00 mg/g) extract. Antioxidant activity was also higher in AP extract. To compare antidiabetic efficacy, we analyzed the effects of R and AP extracts on ɑ-glucosidase inhibition(AGI), dipeptidyl peptidase-4(DPP-4) and protein tyrosine phosphatase(PTP)1B activity. R and AP extracts showed similar effects on AGI and DPP-4 activity in a concentration dependent manner, and there was no effect on PTP1B activation. Glucose uptake(139.51 ± 3.19%) in 3T3-L1 cells was more effective in the AP extract-treated group than the positive control, rosiglitazone, group. Both R and AP extracts were effective in protecting against pancreatic beta cell damage caused by hyperglycemia. These results suggest that Angelica decursiva (Miq.) Franch. & Sav. could be used as a candidate for diabetes treatment.
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Abstract
재료 및 방법
결과 및 고찰
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참고문헌 (4)
참고문헌 신청
Association, A. D. (2021) Introduction: Standards of medical care in diabetes-2021.
Jugran, A. K., Rawat, S., Devkota, H. P., Bhatt, I. D. and Rawal, R. S. (2021) Diabetes and plant-derived natural products: From ethnopharmacological approaches to their potential for modern drug discovery and development. Phytother Res. 35: 223-245.
Plunkett, G. M., Soltis, D. E. and Soltis, P. S. (1996) Evolutionary patterns in apiaceae: inferences based on matK sequence data. Syst Bot. 21: 477-495.
Hong, J. H., Lee, M. J., Jo, Y. I., Moon, S. M., Lee, S. A. and Kim, S. S. (2021) Analytical method validation of cynaroside in domestic Anthriscus sylvestris(L.) Hoffm. leaves extract for standardization as a functional ingredient using RP-HPLC. J Korean Soc Food Sci Nutr. 50: 395-402.
Jugran, A. K., Rawat, S., Devkota, H. P., Bhatt, I. D. and Rawal, R. S. (2021) Diabetes and plant-derived natural products: From ethnopharmacological approaches to their potential for modern drug discovery and development. Phytother Res. 35: 223-245.
Plunkett, G. M., Soltis, D. E. and Soltis, P. S. (1996) Evolutionary patterns in apiaceae: inferences based on matK sequence data. Syst Bot. 21: 477-495.
Hong, J. H., Lee, M. J., Jo, Y. I., Moon, S. M., Lee, S. A. and Kim, S. S. (2021) Analytical method validation of cynaroside in domestic Anthriscus sylvestris(L.) Hoffm. leaves extract for standardization as a functional ingredient using RP-HPLC. J Korean Soc Food Sci Nutr. 50: 395-402.
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