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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.2
- 수록면
- 37 - 51 (15page)
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Th cells, which orchestrate immune responses to various pathogens, differentiate from naïve CD4 T cells into several subsets that stimulate and regulate immune responses against various types of pathogens, as well as a variety of immune-related diseases. Decades of research have revealed that the fate decision processes are controlled by cytokines, cytokine receptor signaling, and master transcription factors that drive the differentiation programs. Since the Th1 and Th2 paradigm was proposed, many subsets have been added to the list. In this review, I will summarize these events, including the fate decision processes, subset functions, transcriptional regulation, metabolic regulation, and plasticity and heterogeneity. I will also introduce current topics of interest.
목차
ABSTRACT
INTRODUCTION
BRIEF HISTORY OF Th SUBSETS
Th CELL FUNCTIONS
SIGNAL TRANSDUCTION AND TRANSCRIPTIONAL REGULATION
EPIGENETIC REGULATION
PLASTICITY AND HETEROGENEITY
METABOLIC REGULATION
CHALLENGES TO THE Th SUBSET PARADIGM
CONCLUSIONS AND PERSPECTIVES
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2023-517-000427218