지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제32권 제4호
- 발행연도
- 2022.4
- 수록면
- 504 - 513 (10page)
- DOI
- 10.4014/jmb.2201.01009
이용수
초록· 키워드
오류제보하기
Chitin deacetylase (CDA) inhibitors were developed as novel antifungal agents because CDA participates in critical fungal physiological and metabolic processes and increases virulence in soilborne fungal pathogens. However, few CDA inhibitors have been reported. In this study, 150 candidate CDA inhibitors were selected from the commercial Chemdiv compound library through structure-based virtual screening. The top-ranked 25 compounds were further evaluated for biological activity. The compound J075-4187 had an IC50 of 4.24 ± 0.16 μM for AnCDA. Molecular docking calculations predicted that compound J075-4187 binds to the amino acid residues, including active sites (H101, D48). Furthermore, compound J075-4187 inhibited food spoilage fungi and plant pathogenic fungi, with minimum inhibitory concentration (MIC) at 260 μg/ml and minimum fungicidal concentration (MFC) at 520 μg/ml. Therefore, compound J075-4187 is a good candidate for use in developing antifungal agents for fungi control.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Defect states in amorphous SiNx:H compounds
한국진공학회 학술발표회초록집
2016 .08
-
Phase transition and magnetic property of La(Fe,Si)13 compound
한국자기학회 학술연구발표회 논문개요집
2021 .11
-
Immune Response to Fungal Pathogens
대한의진균학회지
2020 .01
-
Increased Fungal Infections while using Emerging Therapies (Biologics and Small-molecule Inhibitors) for Treating Skin Diseases: A Review
대한의진균학회지
2021 .09
-
Large-Scale Screening of the Plant Extracts for Antifungal Activity against the Plant Pathogenic Fungi
The Plant Pathology Journal
2022 .12
-
Diffusible and Volatile Antifungal Compounds Produced by an Antagonistic Bacillus velezensis G341 against Various Phytopathogenic Fungi
The Plant Pathology Journal
2017 .10
-
Control of Anthracnose and Gray Mold in Pepper Plants Using Culture Extract of White-Rot Fungus and Active Compound Schizostatin
Mycobiology
2019 .01
-
Antimicrobial and Cytotoxic Activity of Endophytic Fungi from Lagopsis supina
Journal of Microbiology and Biotechnology
2023 .04
-
Antifungal Substances from Streptomyces sp. A3265 Antagonistic to Plant Pathogenic Fungi
Mycobiology
2015 .01
-
Synthesis, Antioxidant and Molecular Docking Studies of (-)-Catechin Derivatives
대한화학회지
2021 .04
-
영상에서 convolutional denoising autoencoder 모형을 이용한 영상복원
한국데이터정보과학회지
2020 .01
-
Novel Approaches for Efficient Antifungal Drug Action
Journal of Microbiology and Biotechnology
2018 .01
-
Two Flavonoid-Based Compounds from Murraya paniculata as Novel Human Carbonic Anhydrase Isozyme II Inhibitors Detected by a Resazurin Yeast-Based Assay
Journal of Microbiology and Biotechnology
2020 .01
-
Synthesis, Docking Study and In-vitro Evaluation of Anti-Tuberculosis Activity of Tri Substituted Imidazoles Containing Quinoline Moiety
대한화학회지
2022 .06
-
Health Effects of Small Volatile Compounds from East Asian Medicinal Mushrooms
Mycobiology
2015 .01
-
Compound Motor design process for high torque
한국자기학회 학술연구발표회 논문개요집
2024 .05
-
한약재 찌꺼기로 제조한 한방보드의 휘발성 성분의 방출 특성
목재공학(Journal of the Korean Wood Science and Technology)
2016 .01
-
Antifungal Activities of Streptomyces blastmyceticus Strain 12-6 Against Plant Pathogenic Fungi
Mycobiology
2019 .01
-
Calcineurin as a Global Fungal Virulence Determinant: Structure Guided Antifungal Development
한국미생물학회 학술대회논문집
2019 .04
-
Antioxidant and Antifungal Activity of Endophytic Fungi Associated with Agarwood Trees
목재공학(Journal of the Korean Wood Science and Technology)
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0