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논문 기본 정보

자료유형
학술저널
저자정보
Kyung-Lak Son (Dongguk University Ilsan Hospital) Dooyoung Jung (Ulsan National Institute of Science and Technology) Kwang-Min Lee (Mind Lab Place Psychiatry Clinic) Chan-Woo Yeom (Uijeongbu Eulji Medical Center) Gyu Han Oh (Seoul National University Hospital) Tae-Yong Kim (Seoul National University Hospital) Seock-Ah Im (Seoul National University Hospital) Kyung-Hun Lee (Seoul National University Hospital) David Spiegel (Stanford University) Bong-Jin Hahm (Seoul National University Hospital)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.5
발행연도
2022.2
수록면
1 - 10 (10page)
DOI
10.3346/jkms.2022.37.e34

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Background: The purpose of this longitudinal prospective cohort study was to investigate the role of chronotype in the incidence of chemotherapy-induced peripheral neuropathy (CIPN) among women with breast cancer. Methods: We recruited women with breast cancer awaiting adjuvant chemotherapy, including four cycles of docetaxel. Participants reported peripheral neuropathy symptoms of numbness/ tingling at the baseline, and at 4weeks after completion of chemotherapy. Candidate psychiatric factors associated with CIPN were assessed at the baseline, using the Composite Scale of Morningness, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale. To examine the association between chronotype and CIPN, we built logistic regression models, adjusting for demographic, clinical, and other psychiatric variables. Results: Among 48 participants, 29 participants developed CIPN. The morning chronotype was inversely associated with CIPN (odds ratio, 0.06; confidence interval, 0.01?0.74; P = 0.028) after adjusting for age, BMI, education, type of operation, alcohol use, smoking, sleep quality, depression, and anxiety. Conclusion: Our results suggest that the morning chronotype is a protective factor against the development of CIPN in patients with breast cancer who were treated with docetaxel.

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