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논문 기본 정보

자료유형
학술저널
저자정보
Jung Jiwon (Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul) Lee Jungmin (Department of Microbiology Institute for Viral Diseases Vaccine Innovation Center College of Medici) Kim Sun-Kyung (Office for Infection Control Asan Medical Center Seoul Korea.) Park Soyeon (Office for Infection Control Asan Medical Center Seoul Korea.) Lim Young-Ju (Office for Infection Control Asan Medical Center Seoul Korea.) Kim Eun Ok (Office for Infection Control Asan Medical Center Seoul Korea.) Park Heedo (Department of Microbiology Institute for Viral Diseases Vaccine Innovation Center College of Medici) Park Man-Seong (Department of Microbiology Institute for Viral Diseases Vaccine Innovation Center College of Medici) Kim Sung-Han (Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.39
발행연도
2022.10
수록면
1 - 6 (6page)
DOI
10.3346/jkms.2022.37.e289

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Background: Patients with hematologic malignancies may produce replication-competent virus beyond 20 days of SARS-CoV-2 infection. However, data regarding the transmission of SARS-CoV-2 from patients with prolonged viral shedding is limited. Methods: In May 2022, four additional cases of COVID-19 were reported in a hematologic ward at a tertiary care hospital in South Korea, after an 8-week isolation of a patient with prolonged viral shedding. We performed whole-genome sequencing (WGS) of SARS-CoV-2 to evaluate the possibility of post-isolation transmission from this prolonged viral shedding. Results: A patient (case 1) with acute myeloid leukemia was released from isolation 54 days after the diagnosis of COVID-19 based on rising Ct value of up to 29.3, and moved to a sixpatient room. On days 10 and 11 post-isolation, his doctor (case 2) and 2 patients who were his roommates (case 3, 4) had positive SARS-CoV-2 PCR results. Additionally, 16 days postisolation, another patient (case 5) in a remote room had positive SARS-CoV-2 PCR result. All the three patients were hospitalized for ≥ 14 days when they were diagnosed with SARS-CoV-2 infection. Except for case 3, the remaining 4 cases were available for WGS, which revealed that case 1 exhibited a 7 nucleotides difference in comparison to cases 4 and 5 and case 2 displayed a 20 nucleotides difference compared with case 1, while sequences of cases 4 and 5 were identical. Conclusions: Despite the possibility of transmission from the patient with prolonged viral shedding, no evidence of the transmission of SARS-CoV-2 from the patient with prolonged positive RT-PCR using WGS was found.

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