Clinical Significance of miR-21-5p in Predicting Occurrence and Progression of Uremic Vascular Calcification in Patients with End-Stage Renal Disease

Rong Wu; Sen Zhou; Minglong Liu; Haiqian An; Zhe Wang; Tianxi Liu

doi:10.3349/ymj.2022.63.3.252

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자료유형: 학술저널

저자정보: Rong Wu (The First Hospital of Lanzhou University Lanzhou China) Sen Zhou (The First Hospital of Lanzhou University Lanzhou China) Minglong Liu (The First Hospital of Lanzhou University Lanzhou China) Haiqian An (The First Hospital of Lanzhou University Lanzhou China) Zhe Wang (The First Hospital of Lanzhou University Lanzhou China) Tianxi Liu (The First Hospital of Lanzhou University Lanzhou China)

저널정보: 연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제63권 제3호

발행연도: 2022.3

수록면: 252 - 258 (7page)

DOI: 10.3349/ymj.2022.63.3.252

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Purpose: Vascular calcification (VC) is a common complication of end-stage renal disease (ESRD). This study aimed to examinechanges in the expression of miR-21-5p in ESRD patients with VC and to explore its clinical value in predicting the occurrenceand progression of uremic VC. Materials and Methods: 120 ESRD patients were divided into patients without VC group (n=38) and patients with VC group(n=82). All patients were followed up for 2 years to evaluate VC progression. qRT-PCR was used to detect serum miR-21-5p levels. Receiver operating characteristic curves were constructed to assess diagnostic value. Kaplan-Meier and log-rank methods wereutilized to calculate associations between VC progression and risk factors. Results: Serum miR-21-5p levels were significantly higher in ESRD patients with VC than in those without VC and increased progressivelywith increasing disease severity. Serum miR-21-5p levels were able to distinguish patients with VC from those withoutVC, with an area under the curve value of 0.883, a sensitivity of 81.7%, and a specificity of 84.2%. After 2 years of follow-up, miR-21-5p expression had increased in patients with worse VC severity, compared with those with stable VC severity. Patients withhigh miR-21-5p levels were more likely to develop more severe VC, indicating an association between miR-21-5p and VC progression(log-rank p=0.002). Multivariable Cox regression analysis suggested that serum miR-21-5p is an independent predictive factorof VC progression in ESRD patients (hazard ratio=2.064, 95% confidence interval=1.225–3.478, p=0.006). Conclusion: miR-21-5p is overexpressed in the serum of ESRD patients with VC. Our results suggest that overexpression of miR-21-5p is closely associated with VC progression.

#End-stage renal disease #vascular calcification #miR-21-5p #clinical value

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