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논문 기본 정보

자료유형
학술저널
저자정보
김윤정 (경북대학교) 김신우 (경북대학교) 장현하 (경북대학교) 권기태 (경북대학교) 황소윤 (경북대학교) 배소현 (경북대학교)
저널정보
연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제63권 제6호
발행연도
2022.6
수록면
499 - 510 (12page)
DOI
10.3349/ymj.2022.63.6.499

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Purpose: Globally, concerns have grown regarding the long-term effects of novel coronavirus disease (COVID-19) infection. Therefore,we evaluated the long-term course of persistent symptoms and patient quality of life. Materials and Methods: This prospective cohort study was conducted at a single tertiary university hospital from August 31, 2020to March 29, 2021 with adult patients followed at 6 and 12 months after acute COVID-19 symptom onset or diagnosis. Clinicalcharacteristics, self-reported symptoms, EuroQol 5 dimension 5 level (EQ5D-5L) index scores, Korean version of the Patient HealthQuestionnaire-9 (PHQ-9), Korean version of the Posttraumatic Stress Disorder Checklist-5 (PCL-5-K), and Generalized AnxietyDisorder-7 (GAD-7) were investigated. Symptom persistent or non-persistent groups were defined according to persistency of COVID-19 related symptoms or signs after acute COVID-19 infection, respectively. Results: Of all 235 patients, 170 (64.6%) patients were eligible for analysis. The median age was 51 (interquartile range, 37–61)years old, and 102 patients were female (60.0%). After 12 months from acute COVID-19 infection, in total, 83 (48.8%) patients stillsuffered from COVID-19-related symptoms. The most common symptoms included amnesia (24.1%), insomnia (14.7%), fatigue(13.5%), and anxiety (12.9%). Among the five EQ5D-5L categories, the average value of anxiety or depression was the most predominant. PHQ-9 and PCL-5-K scores were statistically higher in the COVID-19–related symptom persistent group than the non-persistentgroup (p=0.001). However, GAD-7 scores showed no statistical differences between the two groups (p=0.051). Conclusion: Neuropsychiatric symptoms were the major COVID-19–related symptoms after 12 months from acute COVID-19 infection,reducing quality of life.

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