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논문 기본 정보

자료유형
학술저널
저자정보
La Yeonju (Division of Infectious Diseases Department of Internal Medicine Kangwon National University Hospita) Kim Yong Chan (Division of Infectious Disease Department of Internal Medicine Yongin Severance Hospital Yonsei Uni)
저널정보
대한감염학회 Infection and Chemotherapy Infection and Chemotherapy 제54권 제4호
발행연도
2022.12
수록면
797 - 802 (6page)
DOI
10.3947/ic.2022.0106

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Bone and joint infections (BJI) caused by vancomycin-resistant Enterococcus spp. (VRE) are difficult to treat due to limited antibiotic options. Although linezolid can be used for VRE treatment, it is often discontinued due to time-dependent bone marrow suppression. Daptomycin, a lipopeptide antibiotic agent with rapid bactericidal activity, is another available therapeutic option for VRE infections. We report a case of VRE BJI successfully treated with a high dose of daptomycin plus β-lactam agents. An 84-year-old man received linezolid for the treatment of VRE BJI. After 2 weeks of therapy, the patient experienced bleeding events associated with linezolid-induced bone marrow toxicity and linezolid was discontinued. Next, high-dose daptomycin therapy combined with a β-lactam agent was selected to treat the remaining VRE BJI. During daptomycin treatment, microbiological eradication was achieved, and the patient clinically improved without evidence of adverse events. We highlight the need for daptomycin use for the treatment of VRE infections, especially in cases where linezolid is ineffective.

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