지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.12
- 수록면
- 336 - 351 (16page)
- DOI
- https://doi.org/10.24304/kjcp.2022.32.4.336
이용수
초록· 키워드
오류제보하기
Background: Prader-Willi Syndrome (PWS) is a rare genetic disorder. To improve the health deterioration of PWS, investigatingoptimal treatment options for PWS is required. Thus, we aimed to evaluate the efficacy of pharmacotherapies compared withsupportive care or placebos in patients with PWS. Methods: PubMed and EMBASE databases were used to search for randomizedcontrolled trials (RCTs) evaluating the efficacy of pharmacotherapy in PWS patients. Only RCTs that evaluating the efficacy ofpharmacotherapy in PWS patients were retrieved. Results: A total of 26 studies were included to evaluate body composition,hormones, glucose levels and hyperphagia behavioral status. Pharmacological treatment group showed a significant decrease ofbody fat (mean difference (MD): -6.32, 95% confidence interval (CI): -10.58 to -2.06, p=0.004), a significant increase of lean bodymass (LBM) (MD: 1.86, 95% CI: 1.43 to 2.30, p<0.00001) and insulin-like growth factor 1 (IGF-1) levels (MD: 241.62, 95% CI:68.59 to 414.64, p=0.006) compared with the control group. Nevertheless, based on other outcomes evaluated by the currentsystematic review, pharmacological options showed different efficacy in treating PWS. Conclusion: Pharmacological therapies wereeffective to decrease significantly in body fat and increase significantly on LBM and IGF-1 levels in patients with PWS. However,still, individualized therapies should be considered in real-world practice in PWS treatment.
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