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논문 기본 정보

자료유형
학술저널
저자정보
Young Dong Kim (Departments of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Ko) Cheol Min Shin (Departments of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Ko) Woo-Jin Jeong (Departments of Otorhinolaryngology-Head and Neck Surgery Seoul National University Bundang Hospital) Yang Jin Kim (Departments of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Ko) Hyuk Yoon (Departments of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Ko) Young Soo Park (Departments of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Ko) Nayoung Kim (Departments of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Ko) Dong Ho Lee (Departments of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Ko)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.28 No.4
발행연도
2022.10
수록면
599 - 607 (9page)
DOI
10.5056/jnm21235

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"Background/Aims To evaluate the usefulness of gastroesophageal reflux disease questionnaire (GerdQ) and reflux symptom index (RSI) for diagnosis of gastroesophageal reflux disease (GERD) in patients with suspected laryngopharyngeal reflux (LPR) symptoms (cough, hoarseness, globus, and throat pain). Methods A total of 98 patients with LPR symptoms were incorporated from either gastroenterology or otorhinolaryngology clinic. Patient’s laryngoscopic findings were graded by reflux finding score (RFS), and RFS ≥ 7 was considered as positive LPR. Erosive esophagitis on endoscopy or abnormal results on ambulatory impedance-pH monitoring were used as diagnostic criteria for GERD. Esophageal motor function was evaluated using high-resolution esophageal manometry. Results Ninety-three (94.9%) of the 98 subjects were diagnosed as LPR by RFS, but only 15 (15.3%) had GERD. For GerdQ, the cutoff value of 9 showed the highest area under curve (AUC) to diagnose GERD by receiver operating curve analysis (AUC = 0.565); the sensitivity, specificity, positive predictive value, and negative predictive value were unsatisfactory (50.0%, 70.7%, 22.6%, and 89.2%, respectively.) RSI also showed poor performance in diagnosing GERD; the cutoff value of 25 showed the highest yield (AUC = 0.581); the sensitivity, specificity, positive predictive value, and negative predictive value were 42.9%, 79.3%, 26.1%, and 89.0%, respectively. Ineffective esophageal motility was frequently observed (69 of 98, 70.4%), but there was no difference in esophageal motility parameters between GERD and non-GERD patients. Conclusions In patients with LPR symptoms, significant discrepancies are observed between laryngoscopic diagnosis and GERD. In this population, neither GerdQ nor RSI is useful in diagnosing GERD."

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