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논문 기본 정보

자료유형
학술저널
저자정보
Hye-Kyung Jung (Department of Internal Medicine College of Medicine Ewha Womans University Seoul Korea) Chung Hyun Tae (Department of Internal Medicine Ewha Womans University College of Medicine Seoul Korea) Kyung Ho Song (Department of Internal Medicine CHA University School of Medicine Ilsan Korea) Seung Joo Kang (Department of Internal Medicine Seoul National University Hospital Gangnam Center) Jong Kyu Park (Department of Internal Medicine Gangneung Asan Hospital University of Ulsan College of Medicine) Eun Jeong Gong (Department of Internal Medicine Gangneung Asan Hospital University of Ulsan College of Medicine) Jeong Eun Shin (Department of Internal Medicine Dankook University College of Medicine) Hyun Chul Lim (Department of Internal Medicine Yongin Severance Hospital Yonsei University College of Medicine Yon) Sang Kil Lee (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea) Da Hyun Jung (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea) Yoon Jin Choi (Department of Internal Medicine Severance Hospital Yonsei University College of Medicine Korea) 서승인 (한림대학교) Joon Sung Kim (Department of Internal Medicine Incheon St. Mary’s Hospital College of Medicine The Catholic Univer) Jung Min Lee (Digestive Disease Center CHA Gangnam Medical Center CHA University Seoul Korea) Beom Jin Kim (Department of Internal Medicine Chung-Ang University College of Medicine Seoul Korea) Sun Hyung Kang (Chungnam National University School of Medicine Daejeon Korea) Chan Hyuk Park (Department of Gastroenterology Hanyang University Guri Hospital Guri Korea) Suck Chei Choi (Department of Internal Medicine and Digestive Disease Research Institute Wonkwang University School) Joong Goo Kwon (Department of Internal Medicine Catholic University of Daegu School of Medicine Daegu Korea) Kyung Sik Park (Department of Internal Medicine Keimyung University College of Medicine Daegu Korea) Moo In Park (Department of Internal Medicine Kosin University College of Medicine Busan Korea) Tae Hee Lee (Department of Internal Medicine Soonchunhyang University Hospital Seoul Korea) Seung Young Kim (Department of Internal Medicine College of Medicine Korea University Seoul Korea) Young Sin Cho (Division of Gastroenterology Cheonan Hospital Soonchunhyang University College of Medicine Cheonan) Han Hong Lee (Department of Surgery Seoul St. Mary's Hospital College of Medicine Seoul Korea) Kee Wook Jung (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Ko) Do Hoon Kim (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine) Hee Seok Moon (Department of Internal Medicine Chungnam National University School of Medicine Daejeon Korea) Hirota Miwa (Department of Internal Medicine Hyogo College of Medicine Nishinomiya Hyogo Japan) Chien-Lin Chen (Department of Public Health College of Medicine Tzu Chi University Hualien City Taiwan) Sutep Gonlachanvit (Department of Internal Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand) Uday C Ghoshal (Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow Utt) Justin C Y Wu (Institute of Digestive Disease The Chinese University of Hong Kong) Kewin T H Siah (Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore) Xiaohua Hou (Union Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan China) Tadayuki Oshima (Division of Gastroenterology and Hepatology Department of Internal Medicine Hyogo College of Medici) Miyoung Choi (National Evidence-based Healthcare Collaborating Agency Seoul Korea) Kwang Jae Lee (Department of Gastroenterology Ajou University School of Medicine Suwon Gyeonggi-do Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.27 No.4
발행연도
2021.10
수록면
453 - 481 (29page)
DOI
10.5056/jnm21077

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초록· 키워드

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Gastroesophageal reflux disease (GERD) is a condition in which gastric contents regurgitate into the esophagus or beyond, resulting in either troublesome symptoms or complications. GERD is heterogeneous in terms of varied manifestations, test findings, and treatment responsiveness. GERD diagnosis can be established with symptomatology, pathology, or physiology. Recently the Lyon consensus defined the “proven GERD” with concrete evidence for reflux, including advanced grade erosive esophagitis (Los Angeles classification grades C and or D esophagitis), long-segment Barrett’s mucosa or peptic strictures on endoscopy or distal esophageal acid exposure time > 6% on 24-hour ambulatory pH-impedance monitoring. However, some Asian researchers have different opinions on whether the same standards should be applied to the Asian population. The prevalence of GERD is increasing in Asia. The present evidence-based guidelines were developed using a systematic review and meta-analysis approach. In GERD with typical symptoms, a proton pump inhibitor test can be recommended as a sensitive, cost-effective, and practical test for GERD diagnosis. Based on a meta-analysis of 19 estimated acid-exposure time values in Asians, the reference range upper limit for esophageal acid exposure time was 3.2% (95% confidence interval, 2.7-3.9%) in the Asian countries. Esophageal manometry and novel impedance measurements, including mucosal impedance and a post-reflux swallow-induced peristaltic wave, are promising in discrimination of GERD among different reflux phenotypes, thus increasing its diagnostic yield. We also propose a long-term strategy of evidence-based GERD treatment with proton pump inhibitors and other drugs.

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