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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한임상검사정도관리협회 Journal of Laboratory Medicine And Quality Assurance Laboratory Medicine and Quality Assurance 제44권 제1호
- 발행연도
- 2022.3
- 수록면
- 40 - 47 (8page)
- DOI
- 10.15263/jlmqa.2022.44.1.40
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초록· 키워드
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Background: Current infections are frequently diagnosed based on positive immunoglobulin (Ig) M results, although false positivity can occur. We evaluated cross-reactivity among infectious antibody (Ab) assays.
Methods: A total of 167 positive sera were collected for: rubella IgM and IgG, cytomegalovirus (CMV) IgM and IgG, Toxoplasma gondii (Toxo) IgG, human immunodeficiency virus (HIV) antigen (Ag)/Ab, hepatitis A virus (HAV) IgM and IgG, hepatitis C virus (HCV) Ab, herpes simplex virus (HSV) IgM and IgG, Epstein-Barr virus viral capsid Ag IgM, hepatitis B core (HBc) IgM, hepatitis B e Ab, and severe acute respiratory syndrome coronavirus 2 total Ab, Treponema pallidum IgM (each n=10) and Toxo IgM (n=7). All sera were tested with seven assays in duplicate: Architect rubella IgM, CMV IgM, Toxo IgM, HIV Ag/Ab, HAV IgM, anti-HCV (Abbott Laboratories, USA), and Elecsys HBc IgM (Roche Diagnostics GmbH, Germany). Additionally, sera showing repeatedly reactive were evaluated by following supplemental testing: Elecsys Toxo IgM, HIV Duo and HAV IgM, VIDAS rubella IgM and CMV IgM (bioMerieux SA, France); LIAISON XL CMV IgM (DiaSorin S.p.A., Italy); and HCV blot 3.0 (MP Diagnostics Inc., Philippines).
Results: Except Elecsys HBc IgM, six assays showed reactive for several sera, including other infectious Abs. Upon supplemental testing, Architect rubella IgM, CMV IgM, and anti-HCV showed reactive or gray zone for two sera with HSV IgM (κ=0.903), eight to fifteen with various Abs (κ=0.607?0.814), and one with HAV IgG (κ=0.960), respectively.
Conclusions: Architect rubella IgM, CMV IgM, and anti-HCV showed crossreactivity with reactive sera to other infectious Abs. Considering crossreactivity of Ab assays with other pre-existing infectious Abs, infectious Ab results should be carefully interpreted.
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