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자료유형
학술저널
저자정보
안규대 (웅상중앙병원 진단검사의학과) 김경희 (동아대학교 의과대학 진단검사의학교실)
저널정보
대한수혈학회 대한수혈학회지 대한수혈학회지 제33권 제1호
발행연도
2022.4
수록면
14 - 23 (10page)
DOI
10.17945/kjbt.2022.33.1.14

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Background: Patients with hematologic diseases receive frequent transfusions of red blood cells (RBCs), platelets (PLTs), and fresh frozen plasma (FFP). These patients are more likely to develop alloimmunization due to repeated exposure to RBC antigens. The purpose of this study was to investigate the need for extended RBC matching in patients with hematologic diseases and a history of repeated transfusions. Methods: We assessed patients who had undergone bone marrow examination at the Dong-A University hospital, Busan, South Korea from January 2008 to December 2012. A total of 571 patients were examined. We retrospectively investigated the frequency and volume of the transfusions of RBCs, PLTs, and FFP, the diagnosis of each patient, and the generation of unexpected antibodies. Results: Alloimmunization occurred in 18 out of 571 patients (3.15%). Among the identified antibodies, Rhesus (Rh) group antibodies were the most frequently detected (58.6%). The number of RBC transfusion episodes was higher in the alloimmunized group than that in the non-alloimmunized group (P=0.0016). The RBC transfusion volume was also significantly higher in the alloimmunized group than that in the non-alloimmunized group (P=0.0020). Also, the number of PLT transfusion episodes and transfusion volume were higher in the alloimmunized group. There were no statistically significant differences in the sex, age, or FFP transfusions between the two groups. Conclusion: The number of RBC transfusion episodes and the RBC transfusion volume affected the possibility of generating unexpected antibodies. The number of PLT transfusion episodes and the PLT transfusion volume also affected alloimmunization. The Rh antigen should therefore be matched in elderly patients who are expected to receive repeated blood transfusions. (Korean J Blood Transfus 2022;33:14-23)

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