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학술저널
저자정보
Giordano Katherine R. (BARROW Neurological Institute at Phoenix Children’s Hospital Phoenix AZ 85013 USADepartment of Chil) Law L. Matthew (BARROW Neurological Institute at Phoenix Children’s Hospital Phoenix AZ 85013 USADepartment of Chil) Henderson Jordan (BARROW Neurological Institute at Phoenix Children’s Hospital Phoenix AZ 85013 USADepartment of Ch) Rowe Rachel K. (Department of Integrative Physiology University of Colorado Boulder CO 80309 USA) Lifshitz Jonathan (BARROW Neurological Institute at Phoenix Children’s Hospital Phoenix AZ 85013 USADepartment of Chil)
저널정보
한국뇌신경과학회 Experimental Neurobiology Experimental Neurobiology Vol.31 No.2
발행연도
2022.4
수록면
105 - 115 (11page)
DOI
10.5607/en21027

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Traumatic brain injury (TBI) can affect different regions throughout the brain. Regions near the site of impact are the most vulnerable to injury. However, damage to distal regions occurs. We investigated progressive neuropathology in the dorsal hippocampus (near the impact) and cerebellum (distal to the impact) after diffuse TBI. Adult male rats were subjected to midline fluid percussion injury or sham injury. Brain tissue was stained by the amino cupric silver stain. Neuropathology was quantified in sub-regions of the dorsal hippocampus at 1, 7, and 28 days post-injury (DPI) and coronal cerebellar sections at 1, 2, and 7 DPI. The highest observed neuropathology in the dentate gyrus occurred at 7 DPI which attenuated by 28 DPI, whereas the highest observed neuropathology was at 1 DPI in the CA3 region. There was no significant neuropathology in the CA1 region at any time point. Neuropathology was increased at 7 DPI in the cerebellum compared to shams and stripes of pathology were observed in the molecular layer perpendicular to the cerebellar cortical surface. Together these data show that diffuse TBI can result in neuropathology across the brain. By describing the time course of pathology in response to TBI, it is possible to build the temporal profile of disease progression. Key words: Traumatic brain injury, Neuropathology, Diffuse axonal injury, Silver stain, Hippocampus, Cerebellum

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