지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 533 - 541 (9page)
이용수
초록· 키워드
오류제보하기
Engineered DNA-binding domains provide a powerful technology for numerous biomedical studies due to their ability to recognize specific DNA sequences. Zinc fingers (ZF) are one of the most common DNA-binding domains and have been extensively studied for a variety of applications, such as gene regulation, genome engineering and diagnostics. Another novel DNA-binding domain known as a transcriptional activator-like effector (TALE) has been more recently discovered, which has a previously undescribed DNA-binding mode. Due to their modular architecture and flexibility, TALEs have been rapidly developed into artificial gene targeting reagents. Here, we describe the methods used to design these DNA-binding proteins and their key applications in biomedical research.
목차
등록된 정보가 없습니다.
참고문헌 (76)
참고문헌 신청
Bae, K. H. / 2003 / Human zinc fingers as building blocks in the construction of artificial transcription factors / Nat. Biotechnol 21:275~280
Bailus, B. J. / 2014 / The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders / BMC Neurosci 15:76
Beerli, R. R. / 2002 / Engineering polydactyl zincfinger transcription factors / Nat. Biotechnol 20:135~141
Beerli, R. R. / 1998 / Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks / Proc. Natl. Acad. Sci. USA 95:14628~14633
Beerli, R. R. / 2000 / Positive and negative regulation of endogenous genes by designed transcription factors / Proc. Natl. Acad. Sci. USA 97:1495~1500
Bailus, B. J. / 2014 / The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders / BMC Neurosci 15:76
Beerli, R. R. / 2002 / Engineering polydactyl zincfinger transcription factors / Nat. Biotechnol 20:135~141
Beerli, R. R. / 1998 / Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks / Proc. Natl. Acad. Sci. USA 95:14628~14633
Beerli, R. R. / 2000 / Positive and negative regulation of endogenous genes by designed transcription factors / Proc. Natl. Acad. Sci. USA 97:1495~1500
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cytogenetic Analysis of Bienertia sinuspersici Akhani as the First Step in Genome Sequencing
Genes & Genomics
2020 .01
-
Structure and function of Zalpha, a Z conformation-specific nucleic acid binding domain
Biodesign
2015 .12
-
Structural Analyses of Zinc Finger Domains for Specific Interactions with DNA
Journal of Microbiology and Biotechnology
2016 .12
-
Electrical detection of specific protein binding using DNA-based nano-biosensor
한국진공학회 학술발표회초록집
2016 .08
-
Mass Spectrometric Determination of Zn2+ Binding/Dissociation Constant for Zinc Finger Peptides
Mass Spectrometry Letters
2015 .03
-
DNA-based information storage
한국진공학회 학술발표회초록집
2017 .02
-
DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break Repair
Molecules and Cells
2023 .04
-
[INTERVIEW] THE DNA DETECTIVE DNA 탐정
BBC 사이언스
2022 .06
-
DNA-based data encoding system
한국진공학회 학술발표회초록집
2016 .08
-
MALDI-TOF Analysis of Binding between DNA and Peptides Containing Lysine and Tryptophan
Mass Spectrometry Letters
2015 .09
-
In vivo demonstration of enhanced binding between β-clamp and DnaE of pol III bearing consensus i-CBM
Genes & Genomics
2019 .01
-
Doping Phenomenon by Artificial DNA and MDNA on Two-Dimensional materials
한국진공학회 학술발표회초록집
2020 .08
-
Application of Engineered Zinc Finger Proteins Immobilized on Paramagnetic Beads for Multiplexed Detection of Pathogenic DNA
Journal of Microbiology and Biotechnology
2021 .09
-
In vivo와 in vitro에서 DicA 단백질의 온도 의존적 DNA 결합
미생물학회지
2019 .09
-
Multi-functional Carbon Nanotube Nanocomposites Assembled with DNA-Binding Peptide Anchors
한국진공학회 학술발표회초록집
2020 .08
-
DNA Strand Breaks in Mitotic Germ Cells of Caenorhabditis elegans Evaluated by Comet Assay
Molecules and Cells
2016 .03
-
Effects of the DNA repair inhibitors, cytosine arabinoside and 3‑aminobenzamide, on the frequency of radiation‑induced micronuclei, nuclear buds, and nucleoplasmic bridges
Genes & Genomics
2020 .01
-
Temperature-dependent tendency of target DNA translocation through a nanocapillary functionalized with probe DNA
한국진공학회 학술발표회초록집
2016 .02
-
Selection and Characterization of the Glypican-3 Binding DNA Aptamers
한국미생물학회 학술대회논문집
2016 .04
-
Label-Free Rapid and Simple Detection of Exonuclease III Activity with DNA-Templated Copper Nanoclusters
Journal of Microbiology and Biotechnology
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0