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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.7
- 수록면
- 639 - 645 (7page)
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초록· 키워드
오류제보하기
Liver transplantation is recommended for patients with liver failure, but liver donors are limited. This necessitates the development of artificial livers, and hepatocytes are necessary to develop such artificial livers. Although induced hepatocyte-like cells are used in artificial livers, the characteristics of mouse induced hepatocyte-like cells (miHeps) reprogrammed with embryonic fibroblasts have not yet been clarified. Therefore, this study investigated the mechanisms underlying the survival, function, and death of miHeps. miHeps showed decreased cell viability, increased cytotoxi-city, decreased hepatic function, and albumin and urea secretion at passage 14. Addition of necrostatin-1 (NEC-1) to miHeps inhibited necrosome formation and reactive oxygen species generation and increased cell survival. However, NEC-1 did not affect the hepatic function of miHeps. These results provide a basis for development of artificial livers using hepatocytes.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Afonso, M.B. / 2015 / Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis / Clin. Sci. 129:721~739
Arshad, M.I. / 2015 / The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver / J. Mol. Med. 93:867~878
Cho, Y.S. / 2014 / Perspectives on the therapeutic modulation of an alternative cell death, programmed necrosis (review) / Int. J. Mol. Med. 33:1401~1406
Cho, Y.S. / 2017 / Exploitation of necroptosis for treatment of caspase-compromised cancers / Oncol. Lett. 14:1207~1214
Dasarathy, S. / 2012 / Consilience in sarcopenia of cirrhosis / J. Cachexia, Sarcopenia Muscle 3:225~237
Arshad, M.I. / 2015 / The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver / J. Mol. Med. 93:867~878
Cho, Y.S. / 2014 / Perspectives on the therapeutic modulation of an alternative cell death, programmed necrosis (review) / Int. J. Mol. Med. 33:1401~1406
Cho, Y.S. / 2017 / Exploitation of necroptosis for treatment of caspase-compromised cancers / Oncol. Lett. 14:1207~1214
Dasarathy, S. / 2012 / Consilience in sarcopenia of cirrhosis / J. Cachexia, Sarcopenia Muscle 3:225~237
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