지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 647 - 657 (11page)
- DOI
- 10.14348/molcells.2021.0145
이용수
초록· 키워드
오류제보하기
As a pancreatic inflammatory marker, regenerating islet-derived protein 3A (Reg3A) plays a key role in inflammation-associated pancreatic carcinogenesis by promoting cell proliferation, inhibiting apoptosis, and regulating cancer cell migration and invasion. This study aimed to reveal a novel immuno-regulatory mechanism by which Reg3A modulates tumour-promoting responses during pancreatic cancer (PC) progression. In an in vitro Transwell system that allowed the direct co-culture of human peripheral blood-derived dendritic cells (DCs) and Reg3A-overexpressing/ silenced human PC cells, PC cell-derived Reg3A was found to downregulate CD80, CD83 and CD86 expression on educated DCs, increase DC endocytic function, inhibit DC-induced T lymphocyte proliferation, reduce IL-12p70 production, and enhance IL-23 production by DCs. The positive effect of tumour-derived Reg3A-educated human DCs on PC progression was demonstrated in vivo by intraperitoneally transferring them into PC-implanted severe combined immunodeficiency (SCID) mice reconstituted with human T cells. A Reg3A-JAK2/STAT3 positive feedback loop was identified in DCs educated with Reg3A. In conclusion, as a tumour-derived factor, Reg3A acted to block the differentiation and maturation of the most important antigen-presenting cells, DCs, causing them to limit their potential anti-tumour responses, thus facilitating PC escape and progression.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Balachandran, V. P. / 2019 / Broadening the impact of immunotherapy to pancreatic cancer : challenges and opportunities / Gastroenterology 156:2056~2072
Bazzichetto, C. / 2020 / From genetic alterations to tumor microenvironment: the Ariadne's string in pancreatic cancer / Cells 9:309
Chen, G. / 2016 / Dexmedetomidine inhibits maturation and function of human cord blood-derived dendritic cells by interfering with synthesis and secretion of IL-12 and IL-23 / PLoS One 11:e0153288
Chen, I. L. / 2020 / Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells / Arch. Toxicol 94:2097~2112
Chyuan, I.T. / 2020 / New insights into the IL-12 and IL-23: from a molecular basis to clinical application in immune-mediated inflammation and cancers / Biochem. Pharmacol 175:113928
Bazzichetto, C. / 2020 / From genetic alterations to tumor microenvironment: the Ariadne's string in pancreatic cancer / Cells 9:309
Chen, G. / 2016 / Dexmedetomidine inhibits maturation and function of human cord blood-derived dendritic cells by interfering with synthesis and secretion of IL-12 and IL-23 / PLoS One 11:e0153288
Chen, I. L. / 2020 / Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells / Arch. Toxicol 94:2097~2112
Chyuan, I.T. / 2020 / New insights into the IL-12 and IL-23: from a molecular basis to clinical application in immune-mediated inflammation and cancers / Biochem. Pharmacol 175:113928
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
PROJECTIONS OF ALGEBRAIC VARIETIES WITH ALMOST LINEAR PRESENTATION I
충청수학회지
2019 .01
-
Induction of Regulatory Dendritic Cells by Lactobacillus paracasei L9 Prevents Allergic Sensitization to Bovine β-Lactoglobulin in Mice
Journal of Microbiology and Biotechnology
2015 .01
-
Agonist (P1) Antibody Converts Stem Cells into Migrating Beta-Like Cells in Pancreatic Islets
Journal of Microbiology and Biotechnology
2022 .12
-
Mychonastes sp. 246 Suppresses Human Pancreatic Cancer Cell Growth via IGFBP3-PI3K-mTOR Signaling
Journal of Microbiology and Biotechnology
2023 .04
-
Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System
Molecules and Cells
2021 .01
-
대학생의 운동습관과 체온조절반응
한국지역사회생활과학회지
2015 .08
-
Immunosuppressive Effects of Bryoria sp. (Lichen-Forming Fungus) Extracts via Inhibition of CD8+ T-Cell Proliferation and IL-2 Production in CD4+ T Cells
Journal of Microbiology and Biotechnology
2017 .06
-
Gossypol Induces Apoptosis of Human Pancreatic Cancer Cells via CHOP/Endoplasmic Reticulum Stress Signaling Pathway
Journal of Microbiology and Biotechnology
2022 .05
-
DC23, a Triazolothione Resorcinol Analogue, Is Extensively Metabolized to Glucuronide Conjugates in Human Liver Microsomes
Mass Spectrometry Letters
2018 .03
-
Mechanisms involved in modification of film structure and properties in ICP assisted dc and pulsed dc sputtering
한국진공학회 학술발표회초록집
2015 .08
-
GATA2-Mediated Transcriptional Activation of Notch3 Promotes Pancreatic Cancer Liver Metastasis
Molecules and Cells
2022 .05
-
MicroRNA 449c Mediates the Generation of Monocytic Myeloid-Derived Suppressor Cells by Targeting STAT6
Molecules and Cells
2020 .01
-
Regulatory T Cells Promote Pancreatic Islet Function and Viability via TGF-1 in vitro and in vivo
대한임상검사과학회지
2018 .01
-
Bioinformatics analysis and experimental validation reveal that CDC20 overexpression promotes bladder cancer progression and potential underlying mechanisms
Genes & Genomics
2024 .04
-
A Novel Metabolic Detour for Pancreatic Cancer Survival
Molecules and Cells
2023 .06
-
Overexpression of TRIM44 mediates the NF-κB pathway to promote the progression of ovarian cancer
Genes & Genomics
2024 .06
-
CD133 Regulates IL-1β Signaling and Neutrophil Recruitment in Glioblastoma
Molecules and Cells
2017 .07
-
Effects of thymosin β4-derived peptides on migration and invasion of ovarian cancer cells
Genes & Genomics
2021 .08
-
Single-cell transcriptomic analysis reveals transcriptional and cell subpopulation differences between human and pig immune cells
Genes & Genomics
2024 .03
-
Molecular Imaging Development Consisting of a Specific Peptide Probe Pancreatic Cancer
한국미생물학회 학술대회논문집
2022 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0