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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 900 - 910 (11page)
- DOI
- 10.14348/molcells.2021.0205
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초록· 키워드
오류제보하기
Sour is one of the fundamental taste modalities that enable taste perception in animals. Chemoreceptors embedded in taste organs are pivotal to discriminate between different chemicals to ensure survival. Animals generally prefer slightly acidic food and avoid highly acidic alternatives. We recently proposed that all acids are aversive at high concentrations, a response that is mediated by low pH as well as specific anions in Drosophila melanogaster. Particularly, some carboxylic acids such as glycolic acid, citric acid, and lactic acid are highly attractive to Drosophila compared with acetic acid. The present study determined that attractive carboxylic acids were mediated by broadly expressed Ir25a and Ir76b, as demonstrated by a candidate mutant library screen. The mutant deficits were completely recovered via wild-type cDNA expression in sweet-sensing gustatory receptor neurons. Furthermore, sweet gustatory receptors such as Gr5a, Gr61a, and Gr64a-f modulate attractive responses. These genetic defects were confirmed using binary food choice assays as well as electrophysiology in the labellum. Taken together, our findings demonstrate that at least two different kinds of receptors are required to discriminate attractive carboxylic acids from other acids.
목차
등록된 정보가 없습니다.
참고문헌 (53)
참고문헌 신청
Abuin, L. / 2011 / Functional architecture of olfactory ionotropic glutamate receptors / Neuron 69:44~60
Al-Anzi, B. / 2006 / Response of Drosophila to wasabi is mediated by painless, the fly homolog of mammalian TRPA1/ANKTM1 / Curr. Biol. 16:1034~1040
Benton, R. / 2009 / Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila / Cell 136:149~162
Cameron, P. / 2010 / The molecular basis for water taste in Drosophila / Nature 465:91~95
Chen, Y. / 2017 / Ionotropic receptors mediate Drosophila oviposition preference through sour gustatory receptor neurons / Curr. Biol 27:2741~2750.e4
Al-Anzi, B. / 2006 / Response of Drosophila to wasabi is mediated by painless, the fly homolog of mammalian TRPA1/ANKTM1 / Curr. Biol. 16:1034~1040
Benton, R. / 2009 / Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila / Cell 136:149~162
Cameron, P. / 2010 / The molecular basis for water taste in Drosophila / Nature 465:91~95
Chen, Y. / 2017 / Ionotropic receptors mediate Drosophila oviposition preference through sour gustatory receptor neurons / Curr. Biol 27:2741~2750.e4
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