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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제47권 제1호
- 발행연도
- 2017.1
- 수록면
- 1 - 10 (10page)
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초록· 키워드
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There is an increasing demand for the development of functional photosensitizing nano-sized drugs.
Fullerene, one of the new carbon molecules, has been considered to be a useful and versatile material for this purpose. Notably, fullerenes are water-insoluble, and they readily aggregate in aqueous solution. Therefore, fullerenes usually have been coupled with water-soluble, biocompatible, biodegradable polymers (e.g., polysaccharides, proteins, and other functional polymers), achieving their improved water-solubility and biocompatible properties. In particular, when fullerenes are paired with tumor-targeting ligands or stimuli-responsive polymers, these conjugates exhibit enhanced tumor recognition ability and improved tumor inhibition. Some groups encapsulated fullerenes into liposomes or nanoemulsions for various pharmaceutical purposes. This review provides an in-depth understanding of fullerene/polymer nanoparticles for effective fullerenemediated tumor therapy.
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참고문헌 (52)
참고문헌 신청
Asada R / 2014 / Photodynamic anti-cancer effects of fullerene [C60]-PEG complex on fibrosarcomas preferentially over normal fibroblasts in terms of fullerene uptake and cytotoxicity / Mol Cell Biochem 390:175~184
Blazkova I / 2014 / Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging / Electrophoresis 35:1040~1049
Chaudhuri P / 2009 / Fullerenol–cytotoxic conjugates for cancer chemotherapy / ACS Nano 3:2505~2514
Cherniavskyi YK / 2016 / Interaction of C60 fullerenes with asymmetric and curved lipid membranes:a molecular dynamics study / Phys Chem Chem Phys 18:278~284
Dou Z / 2012 / Synthesis of PEGylated fullerene–5-fluorouracil conjugates to enhance the antitumor effect of 5-fluorouracil / Nanoscale 4:4624~4630
Blazkova I / 2014 / Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging / Electrophoresis 35:1040~1049
Chaudhuri P / 2009 / Fullerenol–cytotoxic conjugates for cancer chemotherapy / ACS Nano 3:2505~2514
Cherniavskyi YK / 2016 / Interaction of C60 fullerenes with asymmetric and curved lipid membranes:a molecular dynamics study / Phys Chem Chem Phys 18:278~284
Dou Z / 2012 / Synthesis of PEGylated fullerene–5-fluorouracil conjugates to enhance the antitumor effect of 5-fluorouracil / Nanoscale 4:4624~4630
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