지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 685 - 693 (9page)
- DOI
- 10.5668/JEHS.2020.46.6.685
이용수
초록· 키워드
오류제보하기
Objectives: Recent data indicate that sensitization to mold contributes to the severity and persistence of asthma.
The aim of this study was to investigate relationships between indoor mold concentrations and pulmonary function parameters in asthmatic children with mold sensitization.
Methods: Asthmatic subjects who had a positive result in skin-prick testing to more than one mold allergen, such as Alternaria, Aspergillus, or Penicillium, were enrolled. Their pulmonary function and methacholine challenge test results were collected. Measurements of blood eosinophil, serum IgE, and fractional exhaled nitric oxide (FeNO) were taken. Indoor levels of VOC, CO2, PM10 and PM2.5 in each subject’s house were measured.
We counted mold and bacteria colonies from the subjects’ house air samples.
Results: The mean levels of FEV1, FVC, FEV1/FVC, and FEF25-75 were 82.8±19.7, 87.3±17.9, 85.8±8.3, and 82.3±28.9%, respectively. The mean FeNO level was 19.8±11.2 ppb and the geometric mean (range of one SD) of methacholine PC20 was 3.99 mg/mL (0.67-23.74 mg/mL). The average indoor air pollutant levels were below the recommended levels set by the Ministry of Environment for multiplex buildings. Indoor mold levels showed a significant inverse correlation with methacholine PC20, but not with the baseline pulmonary function parameters.
Conclusion: Indoor mold concentrations are a risk factor for increased bronchial hyperresponsiveness among asthmatic children with mold sensitization. Targeted environmental intervention should be considered for selected asthmatic children with mold sensitization for avoiding severe airway hyperresponsiveness.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
편복양 / 2001 / 소아천식의 최신 지견 / Clinical and Experimental Pediatrics 44(7):727~731
Sheffer AL / 1992 / International consensus report on diagnosis and treatment of asthma / Eur Respir J 5:601~641
이상일 / 2010 / Prevalence of Childhood Asthma in Korea: International Study of Asthma and Allergies in Childhood / Allergy, Asthma & Immunology Research 2(2):61~64
이신혜 / 2019 / Association of Sensitization to Different Aeroallergens With Airway Function and Nasal Patency in Urban Children / Allergy, Asthma & Immunology Research 11(4):572~582
Pongracic JA / 2010 / Differential effects of outdoor versus indoor fungal spores on asthma morbidity in inner-city children / J Allergy Clin Immunol 125:593~539
Sheffer AL / 1992 / International consensus report on diagnosis and treatment of asthma / Eur Respir J 5:601~641
이상일 / 2010 / Prevalence of Childhood Asthma in Korea: International Study of Asthma and Allergies in Childhood / Allergy, Asthma & Immunology Research 2(2):61~64
이신혜 / 2019 / Association of Sensitization to Different Aeroallergens With Airway Function and Nasal Patency in Urban Children / Allergy, Asthma & Immunology Research 11(4):572~582
Pongracic JA / 2010 / Differential effects of outdoor versus indoor fungal spores on asthma morbidity in inner-city children / J Allergy Clin Immunol 125:593~539
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