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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 1 - 10 (10page)
- DOI
- 10.3346/jkms.2021.36.e205
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초록· 키워드
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Background: Preterm infants are prone to sepsis owing to their immature innate immunity and prolonged hospitalization. We aimed to evaluate the association between late-onset sepsis (LOS) during hospitalization and neurodevelopmental delay at 18?24 months of corrected age in very low birth weight infants (VLBWIs), and to ascertain this association when adjusted for perinatal risk factors.
Methods: This is a population-based study of VLBWIs born at 23?32 weeks of gestation between January 2014 and December 2017 who were enrolled in the Korean Neonatal Network. Bayley scales of infant development were evaluated at 18?24 months of corrected age in 2,098 infants. To test for LOS as a risk factor for neurodevelopmental delay, multiple logistic regression was used and adjusted for parental education status and clinical variables.
Results: Blood culture positive LOS was identified in 419 (20.0%) infants. Cognitive and motor delays were found in 392 (18.7%) and 347 (16.5%) infants, respectively. When multivariate analysis was performed, LOS had a significant association with cognitive delay (odds ratio, 1.48; 95% confidence interval, 1.02?2.16), but no association with motor delay in VLBWIs. Both delays were significantly more frequent in cases of intraventricular hemorrhage (IVH) ≥ grade 3, periventricular leukomalacia (PVL), and intrauterine growth restriction (IUGR) and duration of mechanical ventilation. Male sex and necrotizing enterocolitis ≥ grade 2 had an effect on motor delay, whereas paternal college graduation affected cognitive delay.
Conclusion: In VLBWIs with LOS, there is a heightened risk of cognitive delays at 18?24 months of corrected age. Brain injury, such as severe IVH and PVL, duration of mechanical ventilation, and IUGR, were also associated with cognitive and motor delays.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Shane AL / 2017 / Neonatal sepsis / Lancet 390(10104):1770~1780
Leviton A / 2012 / Systemic responses of preterm newborns with presumed or documented bacteraemia / Acta Paediatr 101(4):355~359
Murphy DJ / 1997 / Neonatal risk factors for cerebral palsy in very preterm babies : casecontrol study / BMJ 314(7078):404~408
Wheater M / 2000 / Perinatal infection is an important risk factor for cerebral palsy in very-lowbirthweight infants / Dev Med Child Neurol 42(6):364~367
Stoll BJ / 2004 / Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection / JAMA 292(19):2357~2365
Leviton A / 2012 / Systemic responses of preterm newborns with presumed or documented bacteraemia / Acta Paediatr 101(4):355~359
Murphy DJ / 1997 / Neonatal risk factors for cerebral palsy in very preterm babies : casecontrol study / BMJ 314(7078):404~408
Wheater M / 2000 / Perinatal infection is an important risk factor for cerebral palsy in very-lowbirthweight infants / Dev Med Child Neurol 42(6):364~367
Stoll BJ / 2004 / Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection / JAMA 292(19):2357~2365
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