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논문 기본 정보

자료유형
학술저널
저자정보
송지인 (Asan Medical Center University of Ulsan College of Medicine) 정의석 (울산대학교) 오문연 (울산대학교) 정지윤 (울산대학교) 차태현 (Asan Medical Center University of Ulsan College of Medicine) 고승현 (Asan Medical Center University of Ulsan College of Medicine) 이병섭 (울산대학교) Ellen Ai-Rhan Kim (울산대학교) 김기수 (Asan Medical Center University of Ulsan College of Medicine)
저널정보
대한주산의학회 Perinatology Perinatology Vol.32 No.4
발행연도
2021.12
수록면
177 - 183 (7page)

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Objective: Women with diabetes mellitus (DM) are at high risk for preterm delivery. However, reported findings on the effects of maternal diabetes on the outcome of very low birth weight infants (VLBWIs) are inconsistent. This study compared the mortality and morbidity among VLBWIs born to women with and without DM. Methods: In this retrospective cohort study, we included data on VLBWI without congenital malformations born between April 2013 and September 2020. Neonatal outcomes according to maternal diabetes, type of diabetes, and maternal insulin treatment were compared using multivariate logistic analysis. Results: Of 756 infants, 61 were born to women with DM. Of these 61 mothers, 55 had gestational DM, while 6 had pregestational DM. After adjusting for confounders, it was observed that VLBWI born to women with diabetes were less likely to develop sepsis. The risk of grade 3 or 4 intraventricular hemorrhage (IVH) was higher in the insulin-requiring DM group. There was no significant difference in the mortality of VLBWI under any maternal condition. Conclusion: Maternal diabetes lowers the prevalence of sepsis in VLBWI, which is particularly augmented in the insulin-requiring DM group. However, maternal insulin treatment increases the incidence of severe IVH in VLBWI.

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