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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Microcurrent electrical stimulation(MES) has been used to accelerate recovery of atrophied skeletal muscle.
However, convincing stimulation parameters for suppressing muscle atrophy due to injured sciatic nerve remains unclear. The objective of this study was to investigate the effective intensity of MES on restraining muscle atrophy with rat model underwent sciatic nerve injury(SNI). Twenty-5-week-old Sprague Dawley male rats were equally assigned to five groups : Control group(Control, CON, n = 4), Denervation group(Denervation, D, n = 4), Denervation with MES of 22 μA group(Denervation + 22 μA, D+22, n = 4), Denervation with MES of 100 μA group (Denervation + 100 μA, D+100 n = 4), Denervation with MES of 400 μA group(Denervation + 400 μA, D+400, n = 4). To induce muscle atrophy, all rats in the D, D+22, D+100, and D+400 groups, were subjected to sciatic nerve injury on their right hindlimb and allowed to have 1 week of resting period. Following this period, rats underwent daily MES(60 min/ a day, 5times/1week) for 4 weeks. After that, we investigate morphological changes in muscle volume by using in vivo micro-computed tomography at week 0, 1, 3 and 5. After 5 weeks, the muscle volume had the highest value in D+400 group, and also noticeably increased in D+100 group compared to it in D group. The results of this study imply that MES with current intensities between 100-400 μA can suppress muscle atrophy effectively.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
W.T. Lim / 2016 / Disuse Atrophy of Skeletal Muscle : From Bench to Bedside / Korea Journal of Neural Rehabilitation 6(1):50~55
Y.J. Jung / 2013 / Effects of hemiplegia and pamplegia induced by sciatic nerve injury on both tibiae and lumbar vertebra trabecular bone; Correlation between the magnitude and Rate of Bone loss and baseline bone Quantity(BV/TV)(Masters dissertation)
Robert, W. J / 2004 / The molecular basis of skeletal muscle atrophy / American Journal of Physiology-Cell Physiology 287(4):834~843
G. H. Won / 2001 / Effects of Electromyostimulation and Weight Training on Muscle Morphology and Function / The Korea Journal of Education 40(1):490~498
G. M. Eom / 2003 / Restoration of Motor Function using Electrical Stimulation : Functional Electrical Stimulation(FES) / Journal of the Korean Society of Precision Engineering 20(1):26~35
Y.J. Jung / 2013 / Effects of hemiplegia and pamplegia induced by sciatic nerve injury on both tibiae and lumbar vertebra trabecular bone; Correlation between the magnitude and Rate of Bone loss and baseline bone Quantity(BV/TV)(Masters dissertation)
Robert, W. J / 2004 / The molecular basis of skeletal muscle atrophy / American Journal of Physiology-Cell Physiology 287(4):834~843
G. H. Won / 2001 / Effects of Electromyostimulation and Weight Training on Muscle Morphology and Function / The Korea Journal of Education 40(1):490~498
G. M. Eom / 2003 / Restoration of Motor Function using Electrical Stimulation : Functional Electrical Stimulation(FES) / Journal of the Korean Society of Precision Engineering 20(1):26~35
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